Extensively revised and updated to reflect the current state of knowledge in the study of
aging, the third edition of the bestselling Physiological Basis of Aging and Geriatrics …

Being major sources of reactive oxygen species (ROS), mitochondrial structures are
exposed to high concentrations of ROS and might therefore be particularly susceptible to …

Worldwide there are over 46 million people living with dementia, and this number is
expected to double every 20 years reaching about 131 million by 2050. The cost to the …

The amyloid β‐protein (Aβ) ending at 42 plays a pivotal role in Alzheimer's disease (AD). We
have reported previously that intracellular Aβ42 is associated with neuronal apoptosis in …

Alzheimer's disease (AD) is a progressive disorder that is characterized by the accumulation
of neuropathologic lesions and neurochemical alterations. Ultrastructural investigations in …

Inhibition of the accumulation of amyloid β-peptide (Aβ) and the formation of β-amyloid fibrils
(fAβ) from Aβ, as well as the destabilization of preformed fAβ in the CNS would be attractive …

Alzheimer's disease (AD) is neuropathologically characterized by depositions of
extracellular amyloid and intracellular neurofibrillary tangles, associated with loss of …

Epidemiological and experimental studies have suggested that high dietary intake of fats is
associated with cognitive decline and a significantly increased risk of dementia. Since …

Abstract Ethnopharmacological relevance Tinospora cordifolia (Willd.) Miers
(Menispermaceae) is a Mediterranean herb, used in Ayurvedic, Siddha, Unani, and folk …

Hypoxia-inducible factor (HIF) prolyl 4-hydroxylases are a family of iron-and 2-oxoglutarate-
dependent dioxygenases that negatively regulate the stability of several proteins that have …