We herein present an overview of the upcoming 5th edition of the World Health Organization
Classification of Haematolymphoid Tumours focussing on lymphoid neoplasms. Myeloid …

In chronic infection, inflammation and cancer, the tissue microenvironment controls how
local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in …

Mesenchymal cells are mesoderm-derived stromal cells that are best known for providing
structural support to organs, synthesizing and remodeling the extracellular matrix (ECM) and …

The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid
tissues, producing long-lived antibody secreting plasma cells and memory B cells, which …

Stromal cells (SCs) establish the compartmentalization of lymphoid tissues critical to the
immune response. However, the full diversity of lymph node (LN) SCs remains undefined …

Lymph nodes (LNs) are strategically positioned at dedicated sites throughout the body to
facilitate rapid and efficient immunity. Central to the structural integrity and framework of LNs …

Diabetes is a systemic disease in which patients with diabetes may develop peripheral
neuropathy of the lower extremities and peripheral vascular disease due to long-term …

The theory that cancer-associated fibroblasts (CAFs) are immunosuppressive cells has
prevailed throughout the past decade. However, recent high-throughput, high-resolution …

Antibodies somatically mutate to attain high affinity in germinal centers (GCs). There,
competition between B cell clones and among somatic mutants of each clone drives an …

Teleost fish possess an adaptive immune system associated with each of their mucosal
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …