[HTML][HTML] Chromatin structure in cancer
In the past decade, we have seen the emergence of sequence-based methods to
understand chromosome organization. With the confluence of in situ approaches to capture …
understand chromosome organization. With the confluence of in situ approaches to capture …
[HTML][HTML] Pioneer factors in development and cancer
BD Sunkel, BZ Stanton - IScience, 2021 - cell.com
Transcription factors (TFs) are essential mediators of epigenetic regulation and modifiers of
penetrance. Studies from the past decades have revealed a sub-class of TF that is capable …
penetrance. Studies from the past decades have revealed a sub-class of TF that is capable …
Mammalian evolution of human cis-regulatory elements and transcription factor binding sites
Understanding the regulatory landscape of the human genome is a long-standing objective
of modern biology. Using the reference-free alignment across 241 mammalian genomes …
of modern biology. Using the reference-free alignment across 241 mammalian genomes …
Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance
SG Danielli, E Porpiglia, AJ De Micheli, N Navarro… - Science …, 2023 - science.org
Rhabdomyosarcoma (RMS) is a group of pediatric cancers with features of developing
skeletal muscle. The cellular hierarchy and mechanisms leading to developmental arrest …
skeletal muscle. The cellular hierarchy and mechanisms leading to developmental arrest …
Multiscale 3D genome reorganization during skeletal muscle stem cell lineage progression and aging
Little is known about three-dimensional (3D) genome organization in skeletal muscle stem
cells [also called satellite cells (SCs)]. Here, we comprehensively map the 3D genome …
cells [also called satellite cells (SCs)]. Here, we comprehensively map the 3D genome …
TWIST2-mediated chromatin remodeling promotes fusion-negative rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is a common soft tissue sarcoma in children that resembles
developing skeletal muscle. Unlike normal muscle cells, RMS cells fail to differentiate …
developing skeletal muscle. Unlike normal muscle cells, RMS cells fail to differentiate …
[HTML][HTML] Elevated ASCL1 activity creates de novo regulatory elements associated with neuronal differentiation
Background The pro-neural transcription factor ASCL1 is a master regulator of neurogenesis
and a key factor necessary for the reprogramming of permissive cell types to neurons …
and a key factor necessary for the reprogramming of permissive cell types to neurons …
Recent advances in pediatric cancer research
TA McEachron, LJ Helman - Cancer research, 2021 - AACR
Over the past few years, the field of pediatric cancer has experienced a shift in momentum,
and this has led to new and exciting findings that have relevance beyond pediatric …
and this has led to new and exciting findings that have relevance beyond pediatric …
[HTML][HTML] SIX1 reprograms myogenic transcription factors to maintain the rhabdomyosarcoma undifferentiated state
JY Hsu, EP Danis, S Nance, JH O'Brien, AL Gustafson… - Cell reports, 2022 - cell.com
Rhabdomyosarcoma (RMS) is a pediatric muscle sarcoma characterized by expression of
the myogenic lineage transcription factors (TFs) MYOD1 and MYOG. Despite high …
the myogenic lineage transcription factors (TFs) MYOD1 and MYOG. Despite high …
[HTML][HTML] Construction of a prognostic immune-related LncRNA risk model for lung adenocarcinoma
Y Li, R Shen, A Wang, J Zhao, J Zhou… - Frontiers in cell and …, 2021 - frontiersin.org
Background Lung adenocarcinoma (LUAD) originates mainly from the mucous epithelium
and glandular epithelium of the bronchi. It is the most common pathologic subtype of non …
and glandular epithelium of the bronchi. It is the most common pathologic subtype of non …