Radiation-induced gastrointestinal syndrome is a major complication and limiting factor for
radiotherapy. Tumor suppressor p53 has a protective role in radiation-induced …

Neurodegenerative diseases (NDs) are a group of heterogeneous disorders with a high
socioeconomic burden. Although pharmacotherapy is currently the principal therapeutic …

Summary The interleukin (IL)-22 cytokine can be protective or inflammatory in the intestine. It
is unclear if IL-22 receptor (IL-22Ra1)-mediated protection involves a specific type of …

The intestinal microbiota community is a fundamental component of the human body and
plays a significant regulatory role in maintaining overall health and in the management …

Background: Uranium exposure remains an important environmental legacy and
physiological health concern, with hundreds of abandoned uranium mines located in the …

The most common in vitro model for absorption, distribution, metabolism, and excretion
(ADME) purposes is currently the Caco-2 cell line. However, clear differences in gene and …

Glucagon-like peptide 1 (GLP-1) is a gut-derived hormone secreted by intestinal L cells and
vital for postprandial glycemic control. As open-type enteroendocrine cells, whether L cells …

Clostridioides difficile is an urgent public health threat, causing nearly 250,000 hospital-
acquired infections and over 12,000 deaths annually in the United States. C. difficile is also …