[HTML][HTML] Benzimidazole and its derivatives: Recent Advances (2020-2022)
O Ebenezer, F Oyetunde-Joshua, OD Omotoso… - Results in …, 2023 - Elsevier
Benzimidazoles are fused heterocyclic ring systems containing two nitrogen atoms. They
have vital therapeutic significance in drug discovery. Many clinically approved drugs have …
have vital therapeutic significance in drug discovery. Many clinically approved drugs have …
Recent advances in nitrogen-containing heterocyclic compounds as receptor tyrosine kinase inhibitors for the treatment of cancer: Biological activity and structural …
Erratic cell proliferation is the initial symptom of cancer, which can eventually metastasize to
other organs. Before cancer becomes metastatic, its spread is triggered by pro-angiogenic …
other organs. Before cancer becomes metastatic, its spread is triggered by pro-angiogenic …
An understanding of mechanism-based approaches for 1, 3, 4-oxadiazole scaffolds as cytotoxic agents and enzyme inhibitors
The world's health system is plagued by cancer and a worldwide effort is underway to find
new drugs to treat cancer. There has been a significant improvement in understanding the …
new drugs to treat cancer. There has been a significant improvement in understanding the …
Novel 7-chloro-4-aminoquinoline-benzimidazole hybrids as inhibitors of cancer cells growth: synthesis, antiproliferative activity, in silico ADME predictions, and …
In this study, new 7-chloro-4-aminoquinoline-benzimidazole compounds were synthesized
and characterized by NMR, MS, and elemental analysis. These novel hybrids differ in the …
and characterized by NMR, MS, and elemental analysis. These novel hybrids differ in the …
New natural Eugenol derivatives as antiproliferative agents: synthesis, biological evaluation, and computational studies
Semisynthetic modifications of natural products have bestowed us with many anticancer
drugs. In the present work, a natural product, eugenol, has been modified synthetically to …
drugs. In the present work, a natural product, eugenol, has been modified synthetically to …
Design, synthesis and biological evaluation of new eugenol derivatives containing 1, 3, 4-oxadiazole as novel inhibitors of thymidylate synthase
Natural products and their semi-synthetic analogues have provided many chemotherapeutic
drugs. In the current study, eugenol, a natural anticancer agent, has been modified …
drugs. In the current study, eugenol, a natural anticancer agent, has been modified …
Design, synthesis, and biological evaluation of novel benzimidazole derivatives as anti-cervical cancer agents through PI3K/Akt/mTOR pathway and tubulin inhibition
SS Li, JJ Chen, MM Zhang, WX Wang… - European Journal of …, 2024 - Elsevier
Abstract Phosphatidylinositol 3-kinase (PI3K) is one of the most attractive therapeutic targets
for cervical cancer treatment. In this study, we designed and synthesized a series of …
for cervical cancer treatment. In this study, we designed and synthesized a series of …
Synthesis, molecular modelling and biological evaluation of new 4-aminothiophene and thienopyrimidine compounds
A series of 4-amino-5-substituted-thiophene derivatives 3, 5 and 7, along with their
corresponding thieno [3, 2-d] pyrimidine compounds 4, 6 and 8, were synthesized and …
corresponding thieno [3, 2-d] pyrimidine compounds 4, 6 and 8, were synthesized and …
Synthesis and Characterization of a New Class of Chromene-Azo Sulfonamide Hybrids as Promising Anticancer Candidates with the Exploration of Their EGFR, h …
FF Alblewi, MH Alsehli, ZM Hritani… - International Journal of …, 2023 - mdpi.com
In this study, novel selective antitumor compounds were synthesized based on their
fundamental pharmacophoric prerequisites associated with EGFR inhibitors. A molecular …
fundamental pharmacophoric prerequisites associated with EGFR inhibitors. A molecular …
Biological activities and ecological aspects of Limonium pruinosum (L.) collected from Wadi Hof Eastern Desert, Egypt, as a promising attempt for potential medical …
MH Sultan, R Bedair, OG Ragab… - Biomass Conversion …, 2023 - Springer
Very few researchers have focused on the biological efficacy of Limonium plants. In this
concern, no investigations were commenced to delve into the in vitro and ex vivo biological …
concern, no investigations were commenced to delve into the in vitro and ex vivo biological …