Neurodevelopmental disorders (NDDs), including intellectual disability (ID), autism and
schizophrenia, have high socioeconomic impact, yet poorly understood etiologies. A recent …

By removing Ser/Thr-specific phosphorylations in a multitude of protein substrates in diverse
tissues, Protein Phosphatase type 2A (PP2A) enzymes play essential regulatory roles in …

Energy metabolism is crucial in maintaining cellular homeostasis and adapting to stimuli for
tubular cells. However, the underlying mechanisms remain largely unknown. Here, we …

Toll-like receptors (TLRs) are critical sensors for the detection of potentially harmful
microbes. They are instrumental in initiating innate and adaptive immune responses against …

Protein phosphatase 2A (PP2A) is a large enzyme family responsible for most cellular
Ser/Thr dephosphorylation events. PP2A substrate specificity, localization, and regulation by …

Objective. Liver cancer is one of the most common malignancies, but its prognosis is still
poor. Exploring potential biomarkers is an important direction of tumor research. We intend …

BACKGROUND: PPM1G, a member of the serine/threonine protease family,
dephosphorylates various proteins and may be involved in cancer development. The role …

Simple Summary The number of women diagnosed and dying from endometrial cancer
worldwide continues to rise. The reason for these sad statistics is because unbiased early …

The imbalance in the phosphorylation and the dephosphorylation of proteins leads to
various diseases. Therefore, in vivo, the functions of protein kinases and protein …

Lung cancer is one of the most common types of cancer worldwide, with the highest
incidence and mortality rates. Protein phosphatase, Mg 2+/Mn 2+ dependent 1G (PPM1G) is …