Transcription factor-based biosensors in biotechnology: current state and future prospects
R Mahr, J Frunzke - Applied microbiology and biotechnology, 2016 - Springer
Living organisms have evolved a plethora of sensing systems for the intra-and extracellular
detection of small molecules, ions or physical parameters. Several recent studies have …
detection of small molecules, ions or physical parameters. Several recent studies have …
Transcription factor-based biosensors enlightened by the analyte
R Fernandez-López, R Ruiz, F de la Cruz… - Frontiers in …, 2015 - frontiersin.org
Whole cell biosensors (WCBs) have multiple applications for environmental monitoring,
detecting a wide range of pollutants. WCBs depend critically on the sensitivity and specificity …
detecting a wide range of pollutants. WCBs depend critically on the sensitivity and specificity …
The private life of environmental bacteria: pollutant biodegradation at the single cell level
PI Nikel, R Silva‐Rocha, I Benedetti… - Environmental …, 2014 - Wiley Online Library
Bacteria display considerable cell‐to‐cell heterogeneity in a number of genetic and
physiological traits. Stochastic differences in regulatory patterns (eg at the transcriptional …
physiological traits. Stochastic differences in regulatory patterns (eg at the transcriptional …
Deconvolution of gene expression noise into spatial dynamics of transcription factor–promoter interplay
Á Goñi-Moreno, I Benedetti, J Kim… - ACS synthetic …, 2017 - ACS Publications
Gene expression noise is not only the mere consequence of stochasticity, but also a signal
that reflects the upstream physical dynamics of the cognate molecular machinery. Soil …
that reflects the upstream physical dynamics of the cognate molecular machinery. Soil …
Use of substrate-induced gene expression in metagenomic analysis of an aromatic hydrocarbon-contaminated soil
MJ Meier, ES Paterson, IB Lambert - Applied and environmental …, 2016 - Am Soc Microbiol
Metagenomics allows the study of genes related to xenobiotic degradation in a culture-
independent manner, but many of these studies are limited by the lack of genomic context …
independent manner, but many of these studies are limited by the lack of genomic context …
Biodegradation of p-xylene—a comparison of three psychrophilic Pseudomonas strains through the lens of gene expression
Abstract p-Xylene is considered a recalcitrant compound despite showing a similar aromatic
structure to other BTEXs (benzene, toluene, ethylbenzene, xylene isomers). This study …
structure to other BTEXs (benzene, toluene, ethylbenzene, xylene isomers). This study …
Molecular mechanisms of xylose utilization by Pseudomonas fluorescens: overlapping genetic responses to xylose, xylulose, ribose and mannitol
Bacterial degradation of xylose is sequentially mediated by two enzymes–an isomerase
(XutA) and a xylulokinase (XutB)–with xylulose as an intermediate. P seudomonas …
(XutA) and a xylulokinase (XutB)–with xylulose as an intermediate. P seudomonas …
Development of fluorescent protein-based biosensing strains: A new tool for the detection of aromatic hydrocarbon pollutants in the environment
The major sources for release of hydrocarbons into the environment include the effluents
generated from chemical processing industries and ports. The introduction of such …
generated from chemical processing industries and ports. The introduction of such …
Mining environmental plasmids for synthetic biology parts and devices
E Martínez-García, I Benedetti, A Hueso… - Microbiology …, 2015 - Am Soc Microbiol
The scientific and technical ambition of contemporary synthetic biology is the engineering of
biological objects with a degree of predictability comparable to those made through electric …
biological objects with a degree of predictability comparable to those made through electric …
A model for the spatiotemporal design of gene regulatory circuits
R Stoof, A Wood, A Goni-Moreno - ACS synthetic biology, 2019 - ACS Publications
Mathematical modeling assists the design of synthetic regulatory networks by providing a
detailed mechanistic understanding of biological systems. Models that can predict the …
detailed mechanistic understanding of biological systems. Models that can predict the …