[HTML][HTML] Biomarkers for diagnosis and therapeutic options in hepatocellular carcinoma

YT Chan, C Zhang, J Wu, P Lu, L Xu, H Yuan, Y Feng… - Molecular Cancer, 2024 - Springer
Liver cancer is a global health challenge, causing a significant social-economic burden.
Hepatocellular carcinoma (HCC) is the predominant type of primary liver cancer, which is …

[HTML][HTML] Genetics of hepatocellular carcinoma: from tumor to circulating DNA

C Campani, J Zucman-Rossi, JC Nault - Cancers, 2023 - mdpi.com
Simple Summary In recent years, the genetic landscape of hepatocellular carcinoma (HCC)
has been explored, identifying TERT promoter, CTNNB1, and TP53 as the most frequent …

[HTML][HTML] Significance of TERT Genetic Alterations and Telomere Length in Hepatocellular Carcinoma

JW Jang, JS Kim, HS Kim, KY Tak, SK Lee, HC Nam… - Cancers, 2021 - mdpi.com
Simple Summary Telomerase reverse transcriptase (TERT) mutations are the most frequent
genetic alterations in hepatocellular carcinoma (HCC). However, integrative analysis studies …

TERT promoter mutation in serum cell-free DNA is a diagnostic marker of primary hepatocellular carcinoma in patients with nonalcoholic fatty liver disease

N Akuta, Y Kawamura, M Kobayashi, Y Arase, S Saitoh… - Oncology, 2021 - karger.com
Introduction: It remains unclear whether TERT promoter mutation (TERT C228T) in serum
cell-free DNA (cfDNA) is useful for the diagnosis of hepatocellular carcinoma (HCC) in …

Noncoding RNAs and programmed cell death in hepatocellular carcinoma: Significant role of epigenetic modifications in prognosis, chemoresistance, and tumor …

R Arefnezhad, S Ashna… - Cell Biology …, 2024 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the most common type of liver cancer with a high death
rate in the world. The molecular mechanisms related to the pathogenesis of HCC have not …

[HTML][HTML] Is cell-free DNA testing in hepatocellular carcinoma ready for prime time?

S Jeepalyam, A Sheel, A Ejaz, E Miller… - International journal of …, 2023 - mdpi.com
Revamping the current biomarker landscape of hepatocellular carcinoma (HCC) with cell-
free DNA (cfDNA) could improve overall outcomes. The use of commercially available …

[HTML][HTML] ctDNA as a novel and promising approach for cancer diagnosis: a focus on hepatocellular carcinoma

N Biglari, MS Soltani-Zangbar, J Mohammadian… - EXCLI …, 2023 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the most prevalent forms of cancer worldwide.
Therefore, it is essential to diagnose and treat HCC patients promptly. As a novel discovery …

Post-treatment cell-free DNA as a predictive biomarker in molecular-targeted therapy of hepatocellular carcinoma

T Nakatsuka, H Nakagawa, Y Hayata, T Wake… - Journal of …, 2021 - Springer
Background Liquid biopsies, particularly those involving circulating tumor DNA (ctDNA), are
rapidly emerging as a non-invasive alternative to tumor biopsies. However, clinical …

Applications of molecular barcode sequencing for the detection of low‐frequency variants in circulating tumour DNA from hepatocellular carcinoma

HW Lee, E Kim, KJ Cho, HJ Park, J Seo… - Liver …, 2022 - Wiley Online Library
Purpose Liquid biopsy has emerged as a promising tool for minimally invasive and accurate
detection of various malignancies. We aimed to apply molecular barcode sequencing to …

Circulating DNA changes are predictive of disease progression after transarterial chemoembolization

D Sefrioui, V Verdier, C Savoye‐Collet… - … Journal of Cancer, 2022 - Wiley Online Library
Transarterial chemoembolization (TACE) is used to treat patients with unresectable
hepatocellular carcinoma (HCC). We evaluated the clinical impact of a‐fetoprotein (AFP) …