[HTML][HTML] Adipose-tissue plasticity in health and disease
Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …
organ. While historically viewed as a passive site for energy storage, we now appreciate that …
The cellular and functional complexity of thermogenic fat
P Cohen, S Kajimura - Nature Reviews Molecular Cell Biology, 2021 - nature.com
Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …
in the form of heat. These thermogenic fat cells were originally considered to function solely …
[HTML][HTML] New advances in adaptive thermogenesis: UCP1 and beyond
Brown and beige adipocytes can catabolize stored energy to generate heat, and this distinct
capacity for thermogenesis could be leveraged as a therapy for metabolic diseases like …
capacity for thermogenesis could be leveraged as a therapy for metabolic diseases like …
Brown adipose tissue—a translational perspective
AC Carpentier, DP Blondin, F Haman… - Endocrine …, 2023 - academic.oup.com
Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …
[HTML][HTML] The common and distinct features of brown and beige adipocytes
K Ikeda, P Maretich, S Kajimura - Trends in Endocrinology & Metabolism, 2018 - cell.com
Two types of thermogenic fat cells, brown adipocytes and beige adipocytes, play a key role
in the regulation of systemic energy homeostasis in mammals. Both brown fat and beige fat …
in the regulation of systemic energy homeostasis in mammals. Both brown fat and beige fat …
UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis
K Ikeda, Q Kang, T Yoneshiro, JP Camporez, H Maki… - Nature medicine, 2017 - nature.com
Abstract Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in
brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1 …
brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1 …
[HTML][HTML] Brown adipose tissue energy metabolism in humans
The demonstration of metabolically active brown adipose tissue (BAT) in humans primarily
using positron emission tomography coupled to computed tomography (PET/CT) with the …
using positron emission tomography coupled to computed tomography (PET/CT) with the …
[HTML][HTML] A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat
L Kazak, ET Chouchani, MP Jedrychowski… - Cell, 2015 - cell.com
Thermogenic brown and beige adipose tissues dissipate chemical energy as heat, and their
thermogenic activities can combat obesity and diabetes. Herein the functional adaptations to …
thermogenic activities can combat obesity and diabetes. Herein the functional adaptations to …
[HTML][HTML] UCP1 dependent and independent thermogenesis in brown and beige adipocytes
K Ikeda, T Yamada - Frontiers in endocrinology, 2020 - frontiersin.org
Mammals have two types of thermogenic adipocytes: brown adipocytes and beige
adipocytes. Thermogenic adipocytes express high levels of uncoupling protein 1 (UCP1) to …
adipocytes. Thermogenic adipocytes express high levels of uncoupling protein 1 (UCP1) to …
Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease
MJ Betz, S Enerbäck - Nature Reviews Endocrinology, 2018 - nature.com
Brown fat is emerging as an interesting and promising target for therapeutic intervention in
obesity and metabolic disease. Activation of brown fat in humans is associated with marked …
obesity and metabolic disease. Activation of brown fat in humans is associated with marked …