Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …

Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …

Brown and beige adipocytes can catabolize stored energy to generate heat, and this distinct
capacity for thermogenesis could be leveraged as a therapy for metabolic diseases like …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Two types of thermogenic fat cells, brown adipocytes and beige adipocytes, play a key role
in the regulation of systemic energy homeostasis in mammals. Both brown fat and beige fat …

Abstract Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in
brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1 …

The demonstration of metabolically active brown adipose tissue (BAT) in humans primarily
using positron emission tomography coupled to computed tomography (PET/CT) with the …

Thermogenic brown and beige adipose tissues dissipate chemical energy as heat, and their
thermogenic activities can combat obesity and diabetes. Herein the functional adaptations to …

Mammals have two types of thermogenic adipocytes: brown adipocytes and beige
adipocytes. Thermogenic adipocytes express high levels of uncoupling protein 1 (UCP1) to …

Brown fat is emerging as an interesting and promising target for therapeutic intervention in
obesity and metabolic disease. Activation of brown fat in humans is associated with marked …