Stocking the toolbox—Using preclinical models to understand the development and treatment of immune checkpoint inhibitor‐induced immune‐related adverse …

ML Cina, J Venegas, A Young - Immunological Reviews, 2023 - Wiley Online Library
Cancer patients treated with immune checkpoint inhibitors (ICIs) are susceptible to a broad
and variable array of immune‐related adverse events (irAEs). With increasing clinical use of …

Inflammasomes in breast cancer: the ignition spark of progression and resistance?

S Elgohary, HM El Tayebi - Expert Reviews in Molecular Medicine, 2023 - cambridge.org
Inflammation and immune evasion are major key players in breast cancer (BC) progression.
Recently, the FDA approved the use of anti-programmed death-ligand 1 antibody (anti-PD …

Chronic High-Salt Diet Activates Tumor-Initiating Stem Cells Leading to Breast Cancer Proliferation

L Tucker, U Ali, R Zent, DA Lannigan, JC Rathmell… - Cells, 2024 - mdpi.com
Several chronic inflammatory diseases have been linked to high-salt (HS) diets. Chronic
inflammation is an established causative hallmark of cancer. However, a direct role of HS …

A clinical outcome of the anti-PD-1 therapy of melanoma in polish patients is mediated by population-specific gut microbiome composition

B Pietrzak, K Tomela, A Olejnik-Schmidt, Ł Galus… - Cancers, 2022 - mdpi.com
Simple Summary The gut microbiome develops rapidly after birth and is constantly modified
by many factors, especially, lifestyle, diet, and drugs. It affects the performance of the …

Elucidation of clinical implications Arising from circadian rhythm and insights into the tumor immune landscape in breast cancer

C Sun, H Zhang, Y Li, Y Yu, J Liu, R Liu, C Sun - Heliyon, 2024 - cell.com
Background Circadian rhythm is an internal timing system generated by circadian-related
genes (CRGs). Disruption in this rhythm has been associated with a heightened risk of …

High salt diet induced tumor initiating stem cells mediate breast cancer progression

LM Tucker - 2024 - search.proquest.com
Chronic high-salt (sodium chloride) diet has been associated with various chronic
inflammatory diseases. We have developed a novel chronic HS diet tumor model by …