The age-associated B cell subset has been the focus of increasing interest over the last
decade. These cells have a unique cell surface phenotype and transcriptional signature …

B cells develop from hematopoietic precursor cells in an ordered maturation and selection
process. Extensive studies with many different mouse mutants provided fundamental …

Self-reactive B cell progenitors are eliminated through central tolerance checkpoints, a
process thought to be restricted to the bone marrow in mammals. Here, we identified a …

Protective antibodies in Plasmodium falciparum malaria are only acquired after years of
repeated infections. Chronic malaria exposure is associated with a large increase in atypical …

B cells are essential for humoral immunity, but the role that they have in regulating CD4+ T
cell responses remains controversial. However, new data showing that the transient …

Human immunodeficiency virus (HIV) disease leads to impaired B cell and antibody
responses through mechanisms that remain poorly defined. A unique memory B cell …

Multiple distinct memory B-cell subsets have been identified in humans, but it remains
unclear how their phenotypic diversity corresponds to the type of responses from which they …

The primary objective of population-based newborn screening is the early identification of
asymptomatic infants with a range of severe diseases, for which effective treatment is …

The adaptive immune system consists of T and B cells that express clonally distributed
antigen receptors. To achieve functional adaptive immune responses, antigen-specific T cell …

Secretory immunoglobulin A (SIgA) enhances host-microbiota symbiosis, whereas SIgM
remains poorly understood. We found that gut IgM+ plasma cells (PCs) were more abundant …