Daphnetin (DAP), a coumarin derivative extracted from Daphne species, is biologically
active phytochemical with copious bioactivities including anti-inflammatory, anti-oxidant …

Background Cis-o-hydroxycinnamic acid lactones, referred to as natural coumarin, have a
basic skeleton of benzopyranone in their structure. The natural coumarins are typically found …

Oxidative damage and accumulation of extracellular matrix (ECM) components play a
crucial role in the adverse outcome of cardiac hypertrophy. Evidence suggests that nuclear …

Intervertebral disc degeneration is a natural process during aging and a leading cause of
lower back pain. Here, we generate a comprehensive atlas of nucleus pulposus cells using …

Idiopathic pulmonary fibrosis (IPF) is a chronic and refractory interstitial lung disease.
Although there is no cure for IPF, the development of drugs with improved efficacy in the …

Psoriasis is a common chronic immune-inflammatory disease. Challenges exist in the
present treatment of psoriasis, such as difficulties in transdermal drug administration and …

Background Allergic rhinitis (AR) is an inflammatory disorder of nasal mucosa resulting from
allergen exposure. Daphnetin (DAP) is a coumarin derivative that has various bioactivities …

Objective This investigation aimed to explore the potential of non-ionic surfactant based
niosomal vesicles encapsulating tenoxicam (TN; anti-rheumatic drug) for the treatment of …

Pseudo-allergic reaction is an allergic reaction mediated by nonimmunoglobulin E (IgE),
which does not require prior contact with antigen sensitization and directly leads to mast cell …

As an increasingly well-known derivative of coumarin, daphnetin (7, 8-dithydroxycoumarin)
has demonstrated various pharmacological activities, including anti-inflammation, anti …