Interleukin-1 beta as a target for atherosclerosis therapy: biological basis of CANTOS and beyond

P Libby - Journal of the American College of Cardiology, 2017 - jacc.org
Inflammatory pathways drive atherogenesis and link conventional risk factors to
atherosclerosis and its complications. One inflammatory mediator has come to the fore as a …

[HTML][HTML] Neutrophil-derived cytokines: facts beyond expression

C Tecchio, A Micheletti, MA Cassatella - Frontiers in immunology, 2014 - frontiersin.org
Polymorphonuclear neutrophils, besides their involvement in primary defense against
infections–mainly through phagocytosis, generation of toxic molecules, release of enzymes …

[HTML][HTML] Anti-inflammatory potential of ellagic acid, gallic acid and punicalagin A&B isolated from Punica granatum

LA BenSaad, KH Kim, CC Quah, WR Kim… - … and alternative medicine, 2017 - Springer
Background Punica granatum (pomegranate), an edible fruit originating in the Middle East,
has been used as a traditional medicine for treatment of pain and inflammatory conditions …

The mucosal immune system: master regulator of bidirectional gut–brain communications

N Powell, MM Walker, NJ Talley - Nature reviews Gastroenterology & …, 2017 - nature.com
Communication between the brain and gut is not one-way, but a bidirectional highway
whereby reciprocal signals between the two organ systems are exchanged to coordinate …

Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut

D Groeger, L O'Mahony, EF Murphy, JF Bourke… - Gut …, 2013 - Taylor & Francis
Certain therapeutic microbes, including Bifidobacteria infantis (B. infantis) 35624 exert
beneficial immunoregulatory effects by mimicking commensal-immune interactions; …

Tumour necrosis factor and cancer

F Balkwill - Nature reviews cancer, 2009 - nature.com
Tumour necrosis factor (TNF) is a major inflammatory cytokine that was first identified for its
ability to induce rapid haemorrhagic necrosis of experimental cancers. When efforts to …

Determination of half-maximal inhibitory concentration using biosensor-based protein interaction analysis

S Aykul, E Martinez-Hackert - Analytical biochemistry, 2016 - Elsevier
Half-maximal inhibitory concentration (IC 50) is the most widely used and informative
measure of a drug's efficacy. It indicates how much drug is needed to inhibit a biological …

The role of the kinases RIP1 and RIP3 in TNF-induced necrosis

P Vandenabeele, W Declercq, F Van Herreweghe… - Science …, 2010 - science.org
Tumor necrosis factor (TNF) is a pleiotropic molecule with a crucial role in cellular stress and
inflammation during infection, tissue damage, and cancer. TNF signaling can lead to three …

Host modulation therapy with anti‐inflammatory agents

PM Preshaw - Periodontology 2000, 2018 - Wiley Online Library
Host modulation therapy refers to a treatment concept in which drug therapies are used as
an adjunct to conventional periodontal treatment to ameliorate destructive aspects of the …

[PDF][PDF] Inflammatory pathways in female reproductive health and disease

HN Jabbour, KJ Sales, RD Catalano, JE Norman - Reproduction, 2009 - Citeseer
Inflammation involves alterations to vascular and immune cell function. It is well recognised
that many physiological reproductive events such as ovulation, menstruation, implantation …