Family‐based and case‐control association studies of catechol‐O‐methyltransferase in attention deficit hyperactivity disorder suggest genetic sexual dimorphism

Q Qian, Y Wang, R Zhou, J Li, B Wang… - American Journal of …, 2003 - Wiley Online Library
Attention deficit hyperactivity disorder (ADHD) is the most common childhood‐onset
behavioral disorder. Boys are more often affected than girls. Family, twin, and adoption …

Association between the COMT locus and obsessive‐compulsive disorder in females but not males

JP Alsobrook, AH Zohar, M Leboyer… - American Journal of …, 2002 - Wiley Online Library
A polymorphism in the coding region of catechol‐O‐methyltransferase gene (COMT) was
previously reported to be associated with obsessive‐compulsive disorder (OCD), particularly …

Developmental imaging genetics: linking dopamine function to adolescent behavior

A Padmanabhan, B Luna - Brain and cognition, 2014 - Elsevier
Adolescence is a period of development characterized by numerous neurobiological
changes that significantly influence behavior and brain function. Adolescence is of particular …

Evidence for a susceptibility locus for panic disorder near the catechol-O-methyltransferase gene on chromosome 22

SP Hamilton, SL Slager, GA Heiman, Z Deng… - Biological …, 2002 - Elsevier
Background: A well-characterized single nucleotide polymorphism (472G/A-Val/Met-SNP8)
in the coding sequence of the catechol-O-methyltransferase (COMT) gene leads to a three …

Genetics of obsessive-compulsive disorders: new findings and challenges

MA Grados, J Walkup, S Walford - Brain and development, 2003 - Elsevier
A review of the current state of research in the genetics of obsessive-compulsive disorder
(OCD) is presented. OCD is a neuropsychiatric condition that affects 1–2% of the population …

Personality and polymorphisms of genes involved in aminergic neurotransmission

RP Ebstein, J Benjamin, RH Belmaker - European journal of pharmacology, 2000 - Elsevier
Genetic factors significantly contribute to the determination of human personality traits
assessed by self-report questionnaires. However, only in the past few years have common …

Sexually dimorphic relationship of a 5-HT2A promoter polymorphism with obsessive-compulsive disorder

MA Enoch, BD Greenberg, DL Murphy, D Goldman - Biological Psychiatry, 2001 - Elsevier
Background: In an earlier analysis of 73 subjects from this study, the reduced activity
catechol O-methyltransferase variant was shown to be associated with obsessive …

Exploratory association study between catechol‐O‐methyltransferase (COMT) high/low enzyme activity polymorphism and hypnotizability

P Lichtenberg, R Bachner‐Melman… - American Journal of …, 2000 - Wiley Online Library
Only recently have studies of electrocortical activity, event‐related potentials, and regional
cerebral blood flow begun to shed light on the anatomical and neurobiological …

Comprehensive family‐based association study of the glutamate transporter gene SLC1A1 in obsessive‐compulsive disorder

J Samuels, Y Wang, MA Riddle… - American Journal of …, 2011 - Wiley Online Library
SLC1A1 is a neuronal gluamate transporter genes and is a promising candidate gene for
obsessive-compulsive disorder (OCD)[Leckman and Kim, 2006]. This gene is expressed in …

Childhood Trauma and COMT Genotype Interact to Increase Hippocampal Activation in Resilient Individuals

SJH Van Rooij, JS Stevens, TD Ely, N Fani… - Frontiers in …, 2016 - frontiersin.org
Both childhood trauma and a functional catechol-O-methyltransferase (COMT) genetic
polymorphism have been associated with posttraumatic stress disorder (PTSD) and …