[HTML][HTML] Mechanisms of immunotherapy resistance in cutaneous melanoma: recognizing a shapeshifter

J Thornton, G Chhabra, CK Singh… - Frontiers in …, 2022 - frontiersin.org
Melanoma is one of the seven most common cancers in the United States, and its incidence
is still increasing. Since 2011, developments in targeted therapies and immunotherapies …

Targeting the epigenome in malignant melanoma: Facts, challenges and therapeutic promises

I Anestopoulos, S Kyriakou, V Tragkola… - Pharmacology & …, 2022 - Elsevier
Malignant melanoma is the most lethal type of skin cancer with high rates of mortality.
Although current treatment options provide a short-clinical benefit, acquired-drug resistance …

[HTML][HTML] Global research trends on precision cancer medicine-related rashes (2008-2021): A bibliographic study

F Zhao, R Yu, S Chen, S Zhao, L Sun, Z Xu… - Frontiers in …, 2022 - frontiersin.org
Background Precision cancer medicine-related rashes are a kind of skin and mucous
lesions caused by precision therapy. More and more evidences indicated that such events …

[HTML][HTML] A Review of Current and Pipeline Drugs for Treatment of Melanoma

N Natarelli, SJ Aleman, IM Mark, JT Tran, S Kwak… - Pharmaceuticals, 2024 - mdpi.com
Malignant melanoma is the most aggressive form of skin cancer. Standard treatment options
include surgery, radiation therapy, systemic chemotherapy, targeted therapy, and …

[HTML][HTML] LINC01296 promotes proliferation of cutaneous malignant melanoma by regulating miR-324-3p/MAPK1 axis

K Wang, Q Luo, Y Zhang, X Xie, W Cheng… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Objective: To investigate the functions and potential molecular mechanism of LINC01296
regarding the progression of cutaneous malignant melanoma (CMM) by the regulation of …

Epigenetics and cutaneous neoplasms: from mechanism to therapy

F Gibson, A Hanly, R Fisher, WA Wyant, M Wu… - …, 2023 - Future Medicine
Epigenetics encompasses heritable, reversible gene expression patterns that do not arise
from mutations in genomic DNA but, rather, are regulated by DNA methylation, histone …

[HTML][HTML] Molecular Docking and Intracellular Translocation of Extracellular Vesicles for Efficient Drug Delivery

Y Matsuzaka, R Yashiro - International Journal of Molecular Sciences, 2022 - mdpi.com
Extracellular vesicles (EVs), including exosomes, mediate intercellular communication by
delivering their contents, such as nucleic acids, proteins, and lipids, to distant target cells …

[HTML][HTML] Mechanismen der Immuntherapie-Resistenz bei kutanem Melanom: Erkennen eines Formwandlers

J Thornton, G Chhabra, CK Singh… - Kompass …, 2022 - karger.com
Das Melanom ist eine der sieben häufigsten Krebsarten in den USA und seine Häufigkeit
nimmt weiter zu. Seit 2011 haben die Entwicklungen bei zielgerichteten Therapien und …

[HTML][HTML] Histone Deacetylase 6 Inhibitors as Adjuvants for Targeted and Immune Therapies in Melanoma

MMG Hernandez - 2023 - search.proquest.com
Melanoma is the least common but deadliest type of skin cancer. The standard of care for
melanoma patients includes surgery, targeted therapy, immunotherapy, chemotherapy, and …

The Role of HDAC6 Inhibitors (HDAC6i) on CD47/SIRPa Pathway in Human Melanoma

ZAR Alahmadi - 2022 - search.proquest.com
CD47 is ubiquitously expressed on the surface of cancer cells. Its interaction with SIRPa on
macrophages' surfaces inhibits the phagocytic activity of macrophages. Epigenetics has a …