[HTML][HTML] Neuroinflammation in Alzheimer's disease

IG Onyango, GV Jauregui, M Čarná, JP Bennett Jr… - Biomedicines, 2021 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

[HTML][HTML] Neuropathobiology of COVID-19: the role for glia

ME Tremblay, C Madore, M Bordeleau… - Frontiers in cellular …, 2020 - frontiersin.org
SARS-CoV-2, which causes the Coronavirus Disease 2019 (COVID-19) pandemic, has a
brain neurotropism through binding to the receptor angiotensin-converting enzyme 2 …

[HTML][HTML] Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - … and Targeted Therapy, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Staging of Alzheimer's disease: past, present, and future perspectives

J Therriault, ER Zimmer, AL Benedet… - Trends in molecular …, 2022 - cell.com
For many years Alzheimer's disease (AD) was associated with the dementia stage of the
disease, the tail end of a pathophysiological process that lasts approximately two decades …

Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function

LA Akay, AH Effenberger, LH Tsai - Genes & development, 2021 - genesdev.cshlp.org
Oligodendrocyte precursor cells (OPCs) are not merely a transitory progenitor cell type, but
rather a distinct and heterogeneous population of glia with various functions in the …

The role of glial autophagy in Alzheimer's disease

A Litwiniuk, GR Juszczak, AM Stankiewicz… - Molecular …, 2023 - nature.com
Although Alzheimer's disease is the most pervasive neurodegenerative disorder, the
mechanism underlying its development is still not precisely understood. Available data …

Astroglial asthenia and loss of function, rather than reactivity, contribute to the ageing of the brain

A Verkhratsky, M Augusto-Oliveira, A Pivoriūnas… - … -European Journal of …, 2021 - Springer
Astroglia represent a class of heterogeneous, in form and function, cells known as
astrocytes, which provide for homoeostasis and defence of the central nervous system …

[HTML][HTML] Transgenic mouse models of Alzheimer's disease: an integrative analysis

R Sanchez-Varo, M Mejias-Ortega… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly
individuals worldwide. Disease modeling using murine transgenic mice was first initiated …

[HTML][HTML] Emerging roles of oligodendrocyte precursor cells in neural circuit development and remodeling

JA Buchanan, NM da Costa, L Cheadle - Trends in neurosciences, 2023 - cell.com
Oligodendrocyte precursor cells (OPCs) are non-neuronal brain cells that give rise to
oligodendrocytes, glia that myelinate the axons of neurons in the brain. Classically known …

[HTML][HTML] Role of neuron and glia in Alzheimer's disease and associated vascular dysfunction

S Bandyopadhyay - Frontiers in aging neuroscience, 2021 - frontiersin.org
Amyloidogenicity and vascular dysfunction are the key players in the pathogenesis of
Alzheimer's disease (AD), involving dysregulated cellular interactions. An intricate balance …