Immunohistochemistry (IHC) is an important auxiliary method for pathologists in routine
diagnostic work as well as in basic and clinical research including exploration of biomarkers …

Objectives: The objective of this study was to determine whether measuring post-operative B-
type natriuretic peptides (NPs)(ie, B-type natriuretic peptide [BNP] and N-terminal fragment …

Cancer treatments have evolved from indiscriminate cytotoxic agents to selective genome-
and immune-targeted drugs that have transformed the outcomes of some malignancies …

Continuous diagnostic tests are often used for discriminating between healthy and diseased
populations. For the clinical application of such tests, it is useful to select a cutpoint or …

Gene or protein expression data are usually represented by metric or at least ordinal
variables. In order to translate a continuous variable into a clinical decision, it is necessary to …

Background Cardiopulmonary bypass initiates a systemic inflammatory response syndrome
that is associated with postoperative morbidity and mortality. Steroids suppress inflammatory …

The ability to parse tumors into subsets based on biomarker expression has many clinical
applications; however, there is no global way to visualize the best cut-points for creating …

Background In cancer research, the association between a gene and clinical outcome
suggests the underlying etiology of the disease and consequently can motivate further …

PURPOSE: To define outcome data and prognostic criteria for patients with metastatic renal
cell carcinoma (RCC) treated with interferon-alfa as initial systemic therapy. The data can be …

PURPOSE: To identify prognostic factors and a model predictive for survival in patients with
metastatic renal-cell carcinoma (RCC). PATIENTS AND METHODS: The relationship …