With the aging of the population, the burden of Alzheimer's disease (AD) is rapidly
expanding. More than 5 million people in the US alone are affected with AD and this number …

Objective It is suggested that declines in estrogen around menopause are associated with
declines in cognitive functioning as well as increased risk of depressive symptoms and …

Introduction This study examined whether, among subjects with mild cognitive impairment
(MCI), women progressed at faster rates than men. Methods We examine longitudinal rates …

ContextPostmenopausal women have a greater risk than men of developing Alzheimer
disease, but studies of the effects of estrogen therapy on Alzheimer disease have been …

Estrogen Actions in the Central Nervous System* | Endocrine Reviews | Oxford Academic
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Objective: There is increasing laboratory evidence for a neuroprotective effect of estrogen;
however, the clinical and epidemiologic evidence remains limited and conflicting. We …

Alzheimer's disease (AD) is the leading cause of dementia in the United States and afflicts>
5.7 million Americans in 2018. Therapeutic options remain extremely limited to those that …

The neuroprotective effects of estrogen have been demonstrated consistently in cellular and
animal studies but the evidence in women remains conflicted. We explored the window of …

The present study tested whether environmental enrichment can reduce age-related spatial
reference memory deficits and alter synaptic protein levels in aged female mice. Female …

Several lines of evidence indicate that estrogen affects hippocampal synaptic plasticity
through rapid nongenomic mechanisms, possibly by binding to plasma membrane estrogen …