Abstract The phosphatidylinositol 3-kinase (PI3K)-Akt and the mammalian target of
rapamycin (mTOR) represent two vital intracellular signaling pathways, which are …

Acute myeloid leukemia (AML) is a heterogeneous group of diseases characterized by
uncontrolled proliferation of hematopoietic stem cells in the bone marrow. Malignant cell …

Drug repurposing holds the potential to bring medications with known safety profiles to new
patient populations. Numerous examples exist for the identification of new indications for …

To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC), we
generated a prognostic LSC-associated miRNA signature derived from functionally …

Acute myeloid leukemia (AML) is a highly heterogeneous hematopoietic malignancy
characterized by excessive proliferation and accumulation of immature myeloid blasts in the …

Currently, cancer ranks as the second leading cause of death worldwide, and at the same
time, the burden of cancer continues to increase. The underlying molecular pathways …

Philadelphia chromosome (Ph)–like B-cell acute lymphoblastic leukemia (Ph-like ALL) is
associated with activated JAK/STAT, Abelson kinase (ABL), and/or phosphatidylinositol 3 …

Epigallocatechin gallate (EGCG) is a flavonoid belonging to the chemical class of falvan-3-
ols (catechins) esterified with gallic acid. It is the main catechin found in green tea (Camellia …

B cell leukaemia is one of the most frequent malignancies in the paediatric population, but
also affects a significant proportion of adults in developed countries. The majority of infant …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease caused by the
malignant transformation of immature progenitors primed towards T-cell development …