Identification of drug-target interactions (DTI) is a central task in drug discovery processes. In
this work, a simple but effective regularized least squares integrating with nonlinear kernel …

The ovarian-derived sex steroid hormones dictate the uterine estrous or menstrual cycle in
mammals and are therefore essential to the establishment and maintenance of pregnancy …

Within the mammalian reproductive system sirtuin 1 and 6 (SIRT1, SIRT6) are considered to
contribute to steroid hormone signaling and control of reproductive physiology. Therefore …

The effect of high concentrations of testosterone on ovarian follicle development was
investigated. Primary follicles and granulosa cells were cultured in vitro in media …

In the present study, we investigated the in vitro effects of peroxisome proliferator activated
receptor (PPAR) ligands on PGF 2α secretion and mRNA expression of prostaglandin F …

The present study investigated the influence of the androgen receptor (AR) agonists
testosterone (T) and dihydrotestosterone (DHT), and vinclozolin (Vnz), a fungicide with …

We used our model system for agonism and antagonism of the androgen receptor (AR), in
which the porcine ovarian follicles were exposed on the excessive concentration of an AR …

The ovarian follicle is the major site of sex steroid production in females, hormones that are
crucially required for normal ovarian function and female reproduction. The biosynthesis and …

Hormones and binding proteins can regulate reproduction, but their involvement in sexual
maturation remains to be elucidated. This study describes possible hormonal regulators of …