Mitochondria are implicated in a wide range of functions apart from ATP generation, and,
therefore, constitute one of the most important organelles of cell. Since healthy mitochondria …

Mitochondrial bioenergetic function is a central component of cellular metabolism in health
and disease. Mitochondrial oxidative phosphorylation is critical for maintaining energetic …

The sideroblastic anemias are a heterogeneous group of inherited and acquired disorders
characterized by anemia and the presence of ring sideroblasts in the bone marrow. Ring …

Mitochondrial dysfunction is known to contribute to a range of diseases, and primary
mitochondrial defects strongly impact high‐energy organs such as the heart. Platforms for …

The mitochondrial genome, which contains all of the hereditary information within human
mitochondria, consists of 16,569 base pairs of double-stranded DNA that encode 37 genes …

Mitochondria are dynamic cellular organelles playing many biological roles that are
fundamentally required for cellular functions. The primary role of mitochondria is ATP …

The phenomenon of comorbidity between monogenic and multifactorial diseases suggests
the involvement of a certain common number of genes and biological pathways in the …

Background. Mitochondrial respiratory chain (RC) disorders are a growing group of
disorders with a large variety of clinical presentations ranging from well-defined clinical …

Mitochondrial disease is a broad term that covers a wide range of mitochondrial disorders
and syndromes. Mitochondrial disease is divided into two distinct categories–primary …