Major mood syndromes are among the most common and disabling mental disorders.
However, a lack of clear delineation of their underlying pathophysiological mechanisms is a …

Abstract Objectives The 2018 Canadian Network for Mood and Anxiety Treatments
(CANMAT) and International Society for Bipolar Disorders (ISBD) guidelines provided …

Objectives: Although clinically highly relevant, the recognition and treatment of bipolar mixed
states has played only an underpart in recent guidelines. This WFSBP guideline has been …

Aims To systematically review the literature on the efficacy and tolerability of the major
chronotherapeutic treatments of bipolar disorders (BD)—bright light therapy (LT), dark …

Background Long-term symptomatic status in persons with major depressive and bipolar
disorders treated clinically is not well established, although mood disorders are leading …

These guidelines for the treatment of unipolar depressive disorders systematically review
available evidence pertaining to the biological treatment of patients with major depression …

Abstract Knowledge of psychiatric disease genetics has advanced rapidly during the past
decade with the advent of genome-wide association studies (GWAS). However, less …

Objective: Electroconvulsive therapy (ECT) is regarded by many clinicians as the most
effective treatment for treatment-resistant bipolar depression, but no randomized controlled …

Importance More effective, tolerable interventions for bipolar depression treatment are
needed. Transcranial direct current stimulation (tDCS) is a novel therapeutic modality with …

Background Amotivation, or decisional anhedonia, is a prominent and disabling feature of
depression. However, this aspect of depression remains understudied, and no prior work …