Objective: Accumulating evidence indicates that manic symptoms below the threshold for
hypomania (mixed features) are common in individuals with major depressive disorder. This …

Objective To write clinical guidelines for the use of psychotropic drugs during pregnancy and
breast‐feeding for daily practice in psychiatry, obstetrics and paediatrics. Method As we …

Background Although mania and hypomania define bipolar disorder, depressive episodes
are more common and impairing, with few proven treatments. Adjunctive therapy with …

In psychopathology research, endophenotypes are a subset of biomarkers that indicate
genetic vulnerability independent of clinical state. To date, an explicit expectation is that …

Purpose: This review article provides an overview of the frequency, burden of illness,
diagnosis, and treatment of bipolar disorder (BD) from the perspective of the advanced …

Background While clinical trial evidence has firmly established the efficacy of several
atypical antipsychotics (AAPs) for treating bipolar depression, no randomized controlled …

Abstract Lower Urinary Tract Symptoms (LUTS) are frequently present in the general
population as patients age with approximately a third of individuals experiencing LUTS …

Background: The current paper includes a systematic search of the literature, a detailed
presentation of the results, and a grading of treatment options in terms of efficacy and …

Objectives Rapid cycling is a common and disabling phenomenon in individuals with bipolar
disorders. In the absence of a recent literature examination, this systematic review and meta …

There is considerable diversity in how treatment-resistant depression (TRD) is defined.
However, every definition incorporates the concept that patients with TRD have not …