Upon its secretion from pancreatic β-cells, insulin reaches the liver through the portal
circulation to exert its action and eventually undergo clearance in the hepatocytes. In …

Insulin action is impaired in type 2 diabetes. The functions of the hormone are an integrated
product of insulin secretion from pancreatic β-cells and insulin clearance by receptor …

Objective Expansion of visceral adipose tissue (VAT) and metabolic inflammation are
consequences of obesity and associated with type 2 diabetes (T2DM). Metabolically …

Elevated temperature can have detrimental effects on the physiological performance of
many marine organisms. However, phenotypic plasticity may enable some populations to …

The pathogenesis of human non-alcoholic fatty liver disease (NAFLD) remains unclear, in
particular in the context of its relationship to insulin resistance and visceral obesity. Work on …

Insulin stores lipid in adipocytes and prevents lipolysis and the release of non-esterified fatty
acids (NEFA). Excessive release of NEFA during sustained energy supply and increase in …

Aims/hypothesis The carcinoembryonic antigen-related cell adhesion molecule 1
(CEACAM1) promotes insulin clearance. Mice with global null mutation (Cc1−/−) or with liver …

Melanoma is the most aggressive type of skin cancer with a high incidence and low survival
rate. More than half of melanomas present the activating BRAF mutations, along which …

Impairment of insulin clearance is being increasingly recognized as a critical step in the
development of insulin resistance and metabolic disease. The carcinoembryonic antigen …

Exenatide, a glucagon‐like peptide‐1 receptor agonist, induces insulin secretion. Its role in
insulin clearance has not been adequately examined. Carcinoembryonic antigen‐related …