In addition to physical barriers, neutrophils are considered a part of the first line of immune
defense. They can be found in the bloodstream, with a lifespan of 6–8 h, and in tissue …

It is well established that adaptive immune responses are deficient in early life, contributing
to increased mortality and morbidity. The developmental trajectories of different components …

Type 1 diabetes (T1D) is an autoimmune disease resulting from the self-destruction of
insulin-producing β-cells. Reduced neutrophil counts have been observed in patients with …

Human type 1 diabetes (T1D) is an autoimmune disease associated with major
histocompatibility complex polymorphisms, β-cell autoantibodies, and autoreactive T cells …

Inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) is the most
prominent and evolutionarily conserved endoplasmic reticulum (ER) membrane protein …

Diabetes is a complex, multifactorial group of metabolic diseases characterized by chronic
hyperglycaemia due to pancreatic beta-cell dysfunction and/or loss. It is characterized by an …

Objective—Type 1 diabetes (T1DM) is a proinflammatory state and confers an increased risk
for vascular complications. Toll-like receptors (TLR) could participate in diabetic …

Most of the genetic variation associated with diabetes, through genome-wide association
studies, does not reside in protein-coding regions, making the identification of functional …

Objective Antinuclear antibodies (ANAs) are detected in∼ 18% of females, yet autoimmune
disease develops in only 5–8%. Immunologic differences between ANA‐positive healthy …

Type 1 diabetes is an autoimmune disease caused by the immune‐mediated destruction of
insulin‐producing pancreatic β cells. In recent years, the incidence of type 1 diabetes …