Studies of the physiology and biomechanics of small (∼ 1 cm) organisms are often limited
by the inability to see inside the animal during a behavior or process of interest and by a lack …

Numerous imaging techniques permit evaluation of regional pulmonary function. Contrast-
enhanced CT methods now allow assessment of vasculature and lung perfusion …

High contrast in X-ray medical imaging, while maintaining acceptable radiation dose levels
to the patient, has long been a goal. One of the most promising methods is that of K-edge …

Scientists and clinicians have a keen interest in studying not just the structure of
physiological systems, but their motion also, or more generally their form and function. This …

Synchrotron radiation offers unique properties of coherence, utilized in phase-contrast
imaging, and high flux as well as a wide energy spectrum which allow the selection of very …

To understand the determinants of inhaled aerosol particle distribution and targeting in the
lung, knowledge of regional deposition, lung morphology and regional ventilation, is crucial …

With increasing spatial resolution of regional ventilation and perfusion, it has become more
apparent that ventilation and blood flow are quite heterogeneous in the lung. A number of …

Rationale: Methacholine (Mch) is routinely used to assess bronchial hyperreactivity;
however, little is known about the differences in the lung response pattern between this …

Basic physical concepts of diffusion, convection, and dispersion pertaining to gas transport
in the human airways are reviewed. Their incorporation into quantitative models of gas …

Mechanical ventilation can damage the lungs, a condition called Ventilator-Induced Lung
Injury (VILI). However, the mechanisms leading to VILI at the microscopic scale remain …