Cannabinoids: potential anticancer agents
M Guzman - Nature reviews cancer, 2003 - nature.com
Cannabinoids—the active components of Cannabis sativa and their derivatives—exert
palliative effects in cancer patients by preventing nausea, vomiting and pain and by …
palliative effects in cancer patients by preventing nausea, vomiting and pain and by …
Molecular pathology of malignant gliomas
DN Louis - Annu. Rev. Pathol. Mech. Dis., 2006 - annualreviews.org
Malignant gliomas, the most common type of primary brain tumor, are a spectrum of tumors
of varying differentiation and malignancy grades. These tumors may arise from neural stem …
of varying differentiation and malignancy grades. These tumors may arise from neural stem …
[HTML][HTML] Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma
Recent studies have identified stem cells in brain cancer. However, their relationship to
normal CNS progenitors, including dependence on common lineage-restricted pathways, is …
normal CNS progenitors, including dependence on common lineage-restricted pathways, is …
Microglia function in brain tumors
JJ Watters, JM Schartner… - Journal of neuroscience …, 2005 - Wiley Online Library
Microglia play an important role in inflammatory diseases of the central nervous system
(CNS). These cells have also been identified in brain neoplasms; however, as of yet their …
(CNS). These cells have also been identified in brain neoplasms; however, as of yet their …
Olig gene function in CNS development and disease
Olig1 and Olig2 encode basic helix‐loop‐helix (bHLH) transcription factors that are
expressed in both the developing and mature vertebrate central nervous system. While …
expressed in both the developing and mature vertebrate central nervous system. While …
Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion
L Liu, J Wu, Z Ying, B Chen, A Han, Y Liang, L Song… - Cancer Research, 2010 - AACR
The poor prognosis of malignant gliomas is largely attributed to their highly invasive nature.
The molecular mechanism underlying the invasiveness of glioma cells, however, remains to …
The molecular mechanism underlying the invasiveness of glioma cells, however, remains to …
Mechanisms of angiogenesis in gliomas
O Kargiotis, JS Rao, AP Kyritsis - Journal of neuro-oncology, 2006 - Springer
Gliomas are the most frequent primary tumors of the central nervous system in adults.
Glioblastoma multiforme, the most aggressive form of astrocytic tumors, displays a rapid …
Glioblastoma multiforme, the most aggressive form of astrocytic tumors, displays a rapid …
Frequent epigenetic inactivation of RASSF1A and BLU genes located within the critical 3p21. 3 region in gliomas
L Hesson, I Bieche, D Krex, E Criniere, K Hoang-Xuan… - Oncogene, 2004 - nature.com
RASSF1A is a major tumor suppressor gene located at 3p21. 3. We investigated the role of
aberrant promoter region hypermethylation of RASSF1A in a large series of adult gliomas …
aberrant promoter region hypermethylation of RASSF1A in a large series of adult gliomas …
Frequent epigenetic inactivation of the SLIT2 gene in gliomas
The SLIT family of genes consists of large extracellular matrix-secreted and membrane-
associated glycoproteins. The Slits (Slit1–3) are ligands for the repulsive guidance …
associated glycoproteins. The Slits (Slit1–3) are ligands for the repulsive guidance …
[HTML][HTML] N4-Phenyl-substituted 2-acetylpyridine thiosemicarbazones: cytotoxicity against human tumor cells, structure–activity relationship studies and investigation on …
MA Soares, JA Lessa, IC Mendes, JG Da Silva… - Bioorganic & medicinal …, 2012 - Elsevier
N4-Phenyl 2-acetylpyridine thiosemicarbazone (H2Ac4Ph; N-(phenyl)-2-(1-(pyridin-2-yl)
ethylidene) hydrazinecarbothioamide) and its N4-ortho-,-meta-and-para-fluorophenyl …
ethylidene) hydrazinecarbothioamide) and its N4-ortho-,-meta-and-para-fluorophenyl …