The limited armamentarium against drug-resistant Gram-negative bacilli has led to the
development of several novel β-lactam–β-lactamase inhibitor combinations (BLBLIs). In this …

Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Carbapenem resistance is a major global health problem that seriously compromises the
treatment of infections caused by nosocomial pathogens. Resistance to carbapenems …

ABSTRACT From January 2019 to April 2020, 32 KPC-producing, ceftazidime-avibactam
(CZA)-resistant Klebsiella pneumoniae strains were isolated in a university hospital in …

Serial femtosecond crystallography has opened up many new opportunities in structural
biology. In recent years, several approaches employing light-inducible systems have …

Bacterial resistance mechanisms are continuously and rapidly evolving. This is particularly
true for Gram-negative bacteria. Over the last decade, the strategy to develop new β …

Objectives In order to inform and anticipate potential strategies aimed at combating KPC-
producing Klebsiella pneumoniae infections, we analysed imipenem/relebactam and …

Class A serine β-lactamases (SBLs) are key antibiotic resistance determinants in Gram-
negative bacteria. SBLs neutralize β-lactams via a hydrolytically labile covalent acyl …

Imipenem-relebactam (IR) is a novel beta-lactam/beta-lactamase inhibitor combination
given with cilastatin. It is indicated for the treatment of complicated urinary tract infections …

Context One of the major problems facing health systems is the emergence of resistant
bacteria. Emerge of extended spectrum of bacterial generated β-lactamases, due to genetic …