Exercise metabolism and adaptation in skeletal muscle

JAB Smith, KA Murach, KA Dyar… - Nature Reviews Molecular …, 2023 - nature.com
Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

[HTML][HTML] The regulation of fat metabolism during aerobic exercise

A Muscella, E Stefàno, P Lunetti, L Capobianco… - Biomolecules, 2020 - mdpi.com
Since the lipid profile is altered by physical activity, the study of lipid metabolism is a
remarkable element in understanding if and how physical activity affects the health of both …

Muscle quality in aging: a multi-dimensional approach to muscle functioning with applications for treatment

MS Fragala, AM Kenny, GA Kuchel - Sports medicine, 2015 - Springer
Aging is often accompanied by declines in physical functioning which impedes older adults'
quality of life, sense of independence, and ability to perform daily tasks. Age-related …

Molecular regulation of fatty acid oxidation in skeletal muscle during aerobic exercise

AM Lundsgaard, AM Fritzen, B Kiens - Trends in Endocrinology & …, 2018 - cell.com
This review summarizes how fatty acid (FA) oxidation is regulated in skeletal muscle during
exercise. From the available evidence it seems that acetyl-CoA availability in the …

Sprint interval and endurance training are equally effective in increasing muscle microvascular density and eNOS content in sedentary males

M Cocks, CS Shaw, SO Shepherd… - The Journal of …, 2013 - Wiley Online Library
Key point Optimal vascular function is critical for health, and endurance training (ET) has
previously been shown to be an effective method of improving this. Sprint interval training …

Muscle lipid metabolism: role of lipid droplets and perilipins

PE Morales, JL Bucarey… - Journal of diabetes …, 2017 - Wiley Online Library
Skeletal muscle is one of the main regulators of carbohydrate and lipid metabolism in our
organism, and therefore, it is highly susceptible to changes in glucose and fatty acid (FA) …

Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5

SO Shepherd, M Cocks, KD Tipton… - The Journal of …, 2013 - Wiley Online Library
Key points Increases in aerobic capacity and intramuscular triglyceride (IMTG) utilization are
well‐described adaptations to endurance training (ET) and contribute to improvements in …

Exercise metabolism: fuels for the fire

M Hargreaves, LL Spriet - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
During exercise, the supply of adenosine triphosphate (ATP) is essential for the energy-
dependent processes that underpin ongoing contractile activity. These pathways involve …

Catecholamine-induced lipolysis in adipose tissue and skeletal muscle in obesity

JWE Jocken, EE Blaak - Physiology & behavior, 2008 - Elsevier
Increased fat storage in adipose and non-adipose tissue (eg skeletal muscle) characterizes
the obese insulin resistant state. Disturbances in pathways of lipolysis may play a role in the …

[HTML][HTML] Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins

H Wang, L Hu, K Dalen, H Dorward… - Journal of Biological …, 2009 - ASBMB
Lipolysis is an important metabolic pathway controlling energy homeostasis through
degradation of triglycerides stored in lipid droplets and release of fatty acids. Lipid droplets …