The etiology of the common, sporadic form of Alzheimer's disease (sAD) is unknown. We
hypothesize that tau pathology within select projection neurons with susceptible …

Neurofibrillary tangles, one of the neuropathologic hallmarks of Alzheimer's disease, have a
dynamic lifespan of maturity that associates with progressive neuronal dysfunction and …

To elucidate the role of Tau isoforms and post-translational modification (PTM) stoichiometry
in Alzheimer's disease (AD), we generated a high-resolution quantitative proteomics map of …

Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

Transcellular propagation of protein aggregates, or proteopathic seeds, may drive the
progression of neurodegenerative diseases in a prion-like manner. In tauopathies such as …

Type 2 diabetes (T2DM), Alzheimer's disease (AD), and insulin resistance are age‐related
conditions and increased prevalence is of public concern. Recent research has provided …

Tau aggregation occurs in neurodegenerative diseases including Alzheimer's disease and
many other disorders collectively termed tauopathies. trans-cellular propagation of tau …

Tau phosphorylation is regulated by a balance between tau kinase and phosphatase
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …

JNPL3 transgenic mice expressing a mutant tau protein, which develop neurofibrillary
tangles and progressive motor disturbance, were crossed with Tg2576 transgenic mice …

The brain is a highly compartmentalized organ exceptionally susceptible to accumulation of
metabolic errors. Alzheimer's disease (AD) is the most prevalent neurodegenerative disease …