Diagnosis and treatment of hip and knee osteoarthritis: a review

JN Katz, KR Arant, RF Loeser - Jama, 2021 - jamanetwork.com
Importance Osteoarthritis (OA) is the most common joint disease, affecting an estimated
more than 240 million people worldwide, including an estimated more than 32 million in the …

The role of inflammation in the pathogenesis of osteoarthritis

YY Chow, KY Chin - Mediators of inflammation, 2020 - Wiley Online Library
A joint is the point of connection between two bones in our body. Inflammation of the joint
leads to several diseases, including osteoarthritis, which is the concern of this review …

Update on the epidemiology, risk factors and disease outcomes of osteoarthritis

TW O'Neill, PS McCabe, J McBeth - Best practice & research Clinical …, 2018 - Elsevier
Osteoarthritis (OA) is the most frequent form of arthritis and a leading cause of pain and
disability worldwide. OA can affect any synovial joint, although the hip, knee, hand, foot and …

Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis?

E Mianehsaz, HR Mirzaei, M Mahjoubin-Tehran… - Stem cell research & …, 2019 - Springer
Degenerative disorders of joints, especially osteoarthritis (OA), result in persistent pain and
disability and high costs to society. Nevertheless, the molecular mechanisms of OA have not …

[HTML][HTML] How does hip osteoarthritis differ from knee osteoarthritis?

M Hall, M van der Esch, RS Hinman, G Peat… - Osteoarthritis and …, 2022 - Elsevier
Hip and knee osteoarthritis (OA) are leading causes of global disability. Most research to
date has focused on the knee, with results often extrapolated to the hip, and this extends to …

Animal models of osteoarthritis: classification, update, and measurement of outcomes

EL Kuyinu, G Narayanan, LS Nair… - Journal of orthopaedic …, 2016 - Springer
Osteoarthritis (OA) is one of the most commonly occurring forms of arthritis in the world
today. It is a debilitating chronic illness causing pain and immense discomfort to the affected …

Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implications

J Xie, Y Wang, L Lu, L Liu, X Yu, F Pei - Ageing research reviews, 2021 - Elsevier
Cellular senescence is the inability of cells to proliferate, which has both beneficial and
detrimental effects on tissue development and homeostasis. Chronic accumulation of …

Epidemiology of posttraumatic osteoarthritis

AC Thomas, T Hubbard-Turner… - Journal of athletic …, 2017 - meridian.allenpress.com
Osteoarthritis is a leading cause of disability whose prevalence and incidence continue to
increase. History of joint injury represents an important risk factor for posttraumatic …

Bioinformatics-led discovery of osteoarthritis biomarkers and inflammatory infiltrates

X Hu, S Ni, K Zhao, J Qian, Y Duan - Frontiers in immunology, 2022 - frontiersin.org
The molecular mechanisms of osteoarthritis, the most common chronic disease, remain
unexplained. This study aimed to use bioinformatic methods to identify the key biomarkers …

[HTML][HTML] Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes

F Zhou, J Mei, X Han, H Li, S Yang, M Wang… - … Pharmaceutica Sinica B, 2019 - Elsevier
The objective was to investigate the effect of kinsenoside (Kin) treatments on macrophage
polarity and evaluate the resulting protection of chondrocytes to attenuate osteoarthritis (OA) …