Obesity and osteoporosis have become major global health problems over the last decades
as their prevalence is increasing. The interaction between obesity and bone metabolism is …

The past 15 years have witnessed tremendous progress in the molecular understanding of
osteoblasts, the main bone-forming cells in the vertebrate skeleton. In particular, all of the …

Anorexia nervosa is a psychiatric disorder characterized by altered body image, persistent
food restriction and low body weight, and is associated with global endocrine dysregulation …

In an increasingly obese and ageing population, type 2 diabetes (T2DM) and osteoporotic
fracture are major public health concerns. Understanding how obesity and type 2 diabetes …

Estrogens are important for bone metabolism via a variety of mechanisms in osteoblasts,
osteocytes, osteoclasts, immune cells and other cells to maintain bone mineral density …

The mouse genetic revolution has shown repeatedly that most organs have more functions
than expected. This has led to the realization that, in addition to a molecular and cellular …

Type 2 diabetes mellitus (T2DM) influences bone metabolism, but the relation of T2DM with
bone mineral density (BMD) remains inconsistent across studies. The objective of this study …

Simple Summary Bone is an extremely metabolically active tissue that is regenerated and
repaired over its lifetime by bone remodeling. Most bone diseases are caused by abnormal …

Leptin was initially best known for its role in energy homeostasis and regulation of energy
expenditure. In the past few years we have realized that leptin also plays a major role in …

Osteoporosis and obesity, two disorders of body composition, are growing in prevalence.
Interestingly, these diseases share several features including a genetic predisposition and a …