Diabetes and osteoporosis are both common diseases with increasing prevalences in the
aging population. There is increasing evidence corroborating an association between …

Obesity is characterized by adipose tissue expansion and chronic low-grade inflammation.
Among the inflammatory mediators related to obesity development are the adipokines …

Background: Whereas excess adiposity is presumed to be advantageous for the skeleton,
studies investigating relations between bone strength and fat during youth have been …

Background: Obesity is associated with hyperparathyroidism and increased bone mass and
turnover, but their pathogeneses are unclear. Aims: Our aim was to determine in obesity …

Osteoporosis is a known complication of spinal cord injury (SCI), but its mechanism remains
unknown. The pathogenesis of osteoporosis after SCI is generally considered disuse …

Thiazolidinediones (TZDs) are agonists of the peroxisome proliferator-activated receptor
gamma (PPARγ) nuclear transcription factor. Two members of this drug class, rosiglitazone …

Our understanding of the control of skeletal metabolism has undergone a dynamic shift in
the last two decades, primarily driven by our understanding of energy metabolism. Evidence …

Both central and peripheral leptin administrations reduce body weight, food intake, and
adiposity in ob/ob mice. In this study we compared effects of intracerebroventricular (ICV) …

This review describes the various subtypes of eating disorders and examines factors
associated with the risk of illness. It considers evidence that the development and …

The belief that obesity is protective against osteoporosis has recently come into question.
The latest epidemiologic and clinical studies have shown that a high level of fat mass might …