Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

Targeting inflammation in atherosclerosis—from experimental insights to the clinic

O Soehnlein, P Libby - Nature reviews Drug discovery, 2021 - nature.com
Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …

Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure

AL Koenig, I Shchukina, J Amrute, PS Andhey… - Nature cardiovascular …, 2022 - nature.com
Heart failure represents a major cause of morbidity and mortality worldwide. Single-cell
transcriptomics have revolutionized our understanding of cell composition and associated …

Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction

SA Dick, JA Macklin, S Nejat, A Momen… - Nature …, 2019 - nature.com
Macrophages promote both injury and repair after myocardial infarction, but discriminating
functions within mixed populations remains challenging. Here we used fate mapping …

Cells of the immune system in cardiac remodeling: main players in resolution of inflammation and repair after myocardial infarction

I Kologrivova, M Shtatolkina, T Suslova… - Frontiers in …, 2021 - frontiersin.org
The burden of heart failure (HF), developing after myocardial infarction MI, still represents a
major issue in clinical practice. Failure of appropriate resolution of inflammation during post …

Cardiac monocytes and macrophages after myocardial infarction

C Peet, A Ivetic, DI Bromage… - Cardiovascular research, 2020 - academic.oup.com
Improvements in early interventions after acute myocardial infarction (AMI), notably, the
increased use of timely reperfusion therapy, have increased survival dramatically in recent …

Tissue resident CCR2− and CCR2+ cardiac macrophages differentially orchestrate monocyte recruitment and fate specification following myocardial injury

G Bajpai, A Bredemeyer, W Li, K Zaitsev… - Circulation …, 2019 - Am Heart Assoc
Rationale: Recent advancements have brought to light the origins, complexity, and functions
of tissue-resident macrophages. However, in the context of tissue injury or disease, large …

Macrophages in cardiac remodelling after myocardial infarction

J Yap, J Irei, J Lozano-Gerona, S Vanapruks… - Nature Reviews …, 2023 - nature.com
Myocardial infarction (MI), as a result of thrombosis or vascular occlusion, is the most
prevalent cause of morbidity and mortality among all cardiovascular diseases. The …

Role of the CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications

H Zhang, K Yang, F Chen, Q Liu, J Ni, W Cao… - Frontiers in …, 2022 - frontiersin.org
The CCL2-CCR2 axis is one of the major chemokine signaling pathways that has received
special attention because of its function in the development and progression of …

Biomimetic cell membrane‐coated poly(lactic‐co‐glycolic acid) nanoparticles for biomedical applications

N Jan, A Madni, S Khan, H Shah… - Bioengineering & …, 2023 - Wiley Online Library
Poly (lactic‐co‐glycolic acid)(PLGA) nanoparticles (NPs) are commonly used for drug
delivery because of their favored biocompatibility and suitability for sustained and controlled …