Oestrogens and their receptors contribute broadly to physiology and diseases. In
premenopausal women, endogenous oestrogens protect against cardiovascular, metabolic …

The actions of estrogens and related estrogenic molecules are complex and multifaceted in
both sexes. A wide array of natural, synthetic, and therapeutic molecules target pathways …

A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …

G protein-coupled estrogen receptor 1 (GPER1), is a functional estrogen receptor involved
in estrogen related actions on several systems including processes of the nervous …

Estrogen is involved in numerous physiological and pathophysiological systems. Its role in
driving estrogen receptor-expressing breast cancers is well established, but it also has …

Estrogens have been implicated in the pathogenesis of various cancer types, including
colorectal carcinoma (CRC). Estrogen receptors such as ERα and ERβ activate intracellular …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are posing great threats to
global health within this century. Studies have suggested that estrogen and estrogen …

The endocannabinoid system (ECS) is a lipid cell signaling system involved in the
physiology and homeostasis of the brain and peripheral tissues. Synaptic plasticity …

The colon is the largest hormonally active tissue in the human body. It has been known for
over a hundred years that various hormones and bioactive peptides play important roles in …

Hematopoietic stem cells provide continuous supply of all the immune cells, through
proliferation and differentiation decisions. These decisions are controlled by local bone …