Complete androgen insensitivity syndrome: from bench to bed

N Tyutyusheva, I Mancini, GI Baroncelli… - International journal of …, 2021 - mdpi.com
Complete androgen insensitivity syndrome (CAIS) is due to complete resistance to the
action of androgens, determining a female phenotype in persons with a 46, XY karyotype …

Genetics and epigenetics of bone remodeling and metabolic bone diseases

L Oton-Gonzalez, C Mazziotta, MR Iaquinta… - International Journal of …, 2022 - mdpi.com
Bone metabolism consists of a balance between bone formation and bone resorption, which
is mediated by osteoblast and osteoclast activity, respectively. In order to ensure bone …

Single‐cell RNAseq provides insight into altered immune cell populations in human fracture nonunions

KG Avin, JM Dominguez 2nd, NX Chen… - Journal of …, 2023 - Wiley Online Library
Nonunion describes bone fractures that fail to heal, resulting in the fracture callus failing to
fully ossify or, in atrophic cases, not forming altogether. Fracture healing is regulated, in part …

Aging, obese-insulin resistance, and bone remodeling

N Imerb, C Thonusin, N Chattipakorn… - Mechanisms of Ageing …, 2020 - Elsevier
Aging, obesity, and insulin resistance are known to cause the impairment of bone regulation,
resulting in an imbalance in bone homeostasis and pathological bone. The natural …

Cancer cell–extrinsic roles for the androgen receptor in prostate cancer

AW Hahn, BA Siddiqui, J Leo, E Dondossola… - …, 2023 - academic.oup.com
Given the central role of the androgen receptor (AR) in prostate cancer cell biology, AR-
targeted therapies have been the backbone of prostate cancer treatment for over 50 years …

Management of bone loss due to endocrine therapy during cancer treatment

MI Khan - Osteoporosis International, 2023 - Springer
Bone modifying agents BMAs (oral and IV bisphosphonates, denosumab) are used to treat
bone loss due to endocrine therapy in patients with hormone receptor positive (HR+) early …

Neuropilin 2 in osteoblasts regulates trabecular bone mass in male mice

L Verlinden, S Doms, I Janssens, MB Meyer… - Frontiers in …, 2023 - frontiersin.org
Introduction Neuropilin 2 (NRP2) mediates the effects of class 3 semaphorins and vascular
endothelial growth factor and is implicated in axonal guidance and angiogenesis. Moreover …

An anthropometric study of sexual orientation and gender identity in Thailand

MN Skorska, LA Coome, DE Peragine, M Aitken… - Scientific Reports, 2021 - nature.com
The biodevelopment of psychological sex differentiation is putatively reflected in several
anthropometrics. We examined eight anthropometrics in 1404 Thai participants varying in …

Metabolome-wide mendelian randomization assessing the causal relationship between blood metabolites and bone mineral density

S Chen, W He - Calcified Tissue International, 2023 - Springer
Mounting evidence has supported osteoporosis (OP) as a metabolic disorder. Recent
metabolomics studies have discovered numerous metabolites related to bone mineral …

A realistic mixture of ubiquitous persistent organic pollutants affects bone and cartilage development in zebrafish by interaction with nuclear receptor signaling

G Guerrero-Limón, J Zappia, M Muller - Plos one, 2024 - journals.plos.org
" Persistent organic pollutants (POPs)" have a plethora of deleterious effects on humans and
the environment due to their bioaccumulative, persistent, and mimicking properties …