Estrogen is a steroid hormone that has critical roles in reproductive development, bone
homeostasis, cardiovascular remodeling and brain functions. However, estrogen also …

Next-generation sequencing has allowed identification of millions of somatic mutations and
epigenetic changes in cancer cells. A key challenge in interpreting cancer genomes and …

Excessive inflammation is becoming accepted as a critical factor in many human diseases,
including inflammatory and autoimmune disorders, neurodegenerative conditions, infection …

Tumor necrosis factor–α (TNF-α) is a major mediator of both acute and chronic inflammatory
responses in many diseases. Tristetraprolin (TTP), the prototype of a class of Cys-Cys-Cys …

The mammalian thioredoxin reductases (TrxRs) are a family of selenium-containing pyridine
nucleotide-disulphide oxidoreductases with mechanistic and sequence identity, including a …

This article reviews findings up to the end of 1997 about the inducible transcription factors
(ITFs) c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A …

The messenger RNAs of many proto‐oncogenes, cytokines and lymphokines are targeted
for rapid degradation through AU‐rich elements (AREs) located in their 3′ untranslated …

Inherently unstable mammalian mRNAs contain AU-rich elements (AREs) within their 3′
untranslated regions. Although found 15 years ago, the mechanism by which AREs dictate …

Mice deficient in tristetraprolin (TTP), the prototype of a family of CCCH zinc finger proteins,
develop an inflammatory syndrome mediated by excess tumor necrosis factor alpha (TNF-α) …

Degradation of messenger RNAs (mRNAs) plays an essential role in modulation of gene
expression and in quality control of mRNA biogenesis. Nearly all major mRNA decay …