The delineation of key molecular pathways has enhanced our knowledge of the biology of
tumor microenvironment, tumor dissemination, and carcinogenesis. The complexities of cell …

Virtually all human tumors are deficient in gap junctional communication (GJC) and the
restoration of GJC by forced expression of connexins reduces indices of neoplasia. The …

The gap junction protein connexin43 (Cx43) is thought to be involved in growth control in
several tissues. Using the doxycycline inducible tet-on system, we generated human …

Cells within a tissue continuously interact to coordinate normal tissue functions and maintain
homeostasis. Gap junctional communication (GJC), mediated by the connexin protein family …

The bone marrow (BM) is a major organ of breast cancer (BC) dormancy and a common
source of BC resurgence. Gap junctional intercellular communication (GJIC) between BC …

Abstract Background Three-dimensional (3D) culture models are considered to recapitulate
the cell microenvironment in solid tumors, including the extracellular matrix (ECM), cell-cell …

Loss of connexin expression/gap junction intercellular communication (GJIC) has been
correlated with decreased growth control and increased tumorigenesis. Studies utilizing …

Despite the success in detecting breast cancer (BC) early and, with aggressive therapeutic
intervention, BC remains a clinical problem. The bone marrow (BM) is a favorable metastatic …

Carotenoi ds are plant pigments, some of which act as a vital source of vitamin A to all
animals, that appear to have additional benefits to primates. They are potent antioxidants …

Astrocytes, the predominant cell type that are broadly distributed in the brain and spinal
cord, play key roles in maintaining homeostasis of the central nerve system (CNS) in …