Cerebellar Activity in Hemi-Parkinsonian Rats during Volitional Gait and Freezing

V DeAngelo, A Gehan, S Paliwal, K Ho, JD Hilliard… - bioRxiv, 2023 - biorxiv.org
Parkinson's disease is a neurodegenerative disease characterized by gait dysfunction in the
advanced stages of the disease. The unilateral 6-OHDA toxin-induced model is the most …

Characterizing motor and cognitive effects associated with deep brain stimulation in the GPi of hemi-Parkinsonian rats

SR Summerson, B Aazhang… - IEEE Transactions on …, 2014 - ieeexplore.ieee.org
The globus pallidus internus (GPi) is the main output nucleus of the basal ganglia, which is
associated with a variety of functions including motor performance and cognition. The GPi is …

Mechanical behavior and microstructure of porcine brain tissues under pulsed electric fields

Y Li, Q Zhang, J Zhao, Z Wang, X Zong, L Yang… - … and Modeling in …, 2024 - Springer
Pulsed electric fields are extensively utilized in clinical treatments, such as subthalamic
deep brain stimulation, where electric field loading is in direct contact with brain tissue …

Globus pallidus internus deep brain stimulation as rescue therapy for refractory dyskinesias following effective subthalamic nucleus stimulation

RJ Cook, L Jones, G Fracchia, N Anderson… - Stereotactic and …, 2015 - karger.com
Background: Deep brain stimulation (DBS) at the subthalamic nucleus (STN) or globus
pallidus internus (GPi) can effectively treat the motor symptoms of Parkinson's disease, but …

Neural circuits with long-distance axon tracts for determining functional connectivity

MD Tang-Schomer, P Davies, D Graziano… - Journal of neuroscience …, 2014 - Elsevier
The cortical circuitry in the brain consists of structurally and functionally distinct neuronal
assemblies with reciprocal axon connections. To generate cell culture-based systems that …

Beta oscillation detector design for closed-loop deep brain stimulation of Parkinson's disease with memristive spiking neural networks

Z Kerman, C Yu, H An - 2022 23rd International Symposium on …, 2022 - ieeexplore.ieee.org
Deep Brain Stimulation (DBS) is a prominent treatment of Parkinson's disease (PD) that
sends stimulation signals into the brain. The Closed-Loop DBS (CL-DBS) is an adaptive …

Effects of subthalamic deep brain stimulation on blink abnormalities of 6-OHDA lesioned rats

J Kaminer, P Thakur, C Evinger - Journal of …, 2015 - journals.physiology.org
Parkinson's disease (PD) patients and the 6-hydroxydopamine (6-OHDA) lesioned rat model
share blink abnormalities. In view of the evolutionarily conserved organization of blinking …

Patterned low-frequency deep brain stimulation induces motor deficits and modulates cortex-basal ganglia neural activity in healthy rats

CS Oza, DT Brocker, CE Behrend… - Journal of …, 2018 - journals.physiology.org
Deep brain stimulation (DBS) is an effective therapy for movement disorders, including
Parkinson's disease (PD), although the mechanisms of action remain unclear. Abnormal …

[HTML][HTML] Insights into the use of deep brain stimulation as a treatment for Parkinson's disease and related conditions

Z Liu, Y Zhou, Y Gao, X Hu - Frontiers in Neuroscience, 2023 - frontiersin.org
Parkinson's Disease (PD), the second most prevalent progressive neurodegenerative
disorder, manifests through motor symptoms, including resting tremors, rigidity …

Frequency matters: beta‐band subthalamic nucleus deep‐brain stimulation induces P arkinsonian‐like blink abnormalities in normal rats

J Kaminer, P Thakur, C Evinger - European Journal of …, 2014 - Wiley Online Library
The synchronized beta‐band oscillations in the basal ganglia‐cortical networks in
Parkinson's disease (PD) may be responsible for PD motor symptoms or an epiphenomenon …