ATP7A-regulated enzyme metalation and trafficking in the menkes disease puzzle
N Horn, P Wittung-Stafshede - Biomedicines, 2021 - mdpi.com
Copper is vital for numerous cellular functions affecting all tissues and organ systems in the
body. The copper pump, ATP7A is critical for whole-body, cellular, and subcellular copper …
body. The copper pump, ATP7A is critical for whole-body, cellular, and subcellular copper …
PEX5 translocation into and out of peroxisomes drives matrix protein import
ML Skowyra, TA Rapoport - Molecular cell, 2022 - cell.com
Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases.
Most peroxisomal enzymes are imported from the cytosol by the receptor PEX5, which …
Most peroxisomal enzymes are imported from the cytosol by the receptor PEX5, which …
Protein import into peroxisomes occurs through a nuclear pore–like phase
Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases.
Most peroxisomal proteins are imported from the cytosol in a folded state by the soluble …
Most peroxisomal proteins are imported from the cytosol in a folded state by the soluble …
Import and quality control of peroxisomal proteins
M Rudowitz, R Erdmann - Journal of Cell Science, 2023 - journals.biologists.com
Peroxisomes are involved in a multitude of metabolic and catabolic pathways, as well as the
innate immune system. Their dysfunction is linked to severe peroxisome-specific diseases …
innate immune system. Their dysfunction is linked to severe peroxisome-specific diseases …
[HTML][HTML] Structure of a robust bacterial protein cage and its application as a versatile biocatalytic platform through enzyme encapsulation
N Lončar, HJ Rozeboom, LE Franken… - Biochemical and …, 2020 - Elsevier
Using a newly discovered encapsulin from Mycolicibacterium hassiacum, several
biocatalysts were packaged in this robust protein cage. The encapsulin was found to be …
biocatalysts were packaged in this robust protein cage. The encapsulin was found to be …
[HTML][HTML] Development of novel PEX5-PEX14 protein-protein interaction (PPI) inhibitors based on an oxopiperazine template
M Marciniak, P Mróz, V Napolitano, VC Kalel… - European Journal of …, 2023 - Elsevier
Protein-protein interactions (PPIs) constitute an important but challenging class of molecular
targets for small molecules. The PEX5-PEX14 PPI has been shown to play a critical role in …
targets for small molecules. The PEX5-PEX14 PPI has been shown to play a critical role in …
Biogenesis and metabolic homeostasis of trypanosomatid glycosomes: New insights and new questions
PAM Michels, M Gualdrón‐López - Journal of Eukaryotic …, 2022 - Wiley Online Library
Kinetoplastea and Diplonemea possess peroxisome‐related organelles that, uniquely,
contain most of the enzymes of the glycolytic pathway and are hence called glycosomes …
contain most of the enzymes of the glycolytic pathway and are hence called glycosomes …
Delineating transitions during the evolution of specialised peroxisomes: Glycosome formation in kinetoplastid and diplonemid protists
D Andrade-Alviárez, AD Bonive-Boscan… - Frontiers in Cell and …, 2022 - frontiersin.org
One peculiarity of protists belonging to classes Kinetoplastea and Diplonemea within the
phylum Euglenozoa is compartmentalisation of most glycolytic enzymes within peroxisomes …
phylum Euglenozoa is compartmentalisation of most glycolytic enzymes within peroxisomes …
Peroxisomes of the brain: distribution, functions, and associated diseases
R Deb, N Joshi, S Nagotu - Neurotoxicity Research, 2021 - Springer
Peroxisomes are versatile cell organelles that exhibit a repertoire of organism and cell-type
dependent functions. The presence of oxidases and antioxidant enzymes is a characteristic …
dependent functions. The presence of oxidases and antioxidant enzymes is a characteristic …
The diverse roles of peroxisomes in the interplay between viruses and mammalian cells
Peroxisomes are ubiquitous organelles found in eukaryotic cells that play a critical role in
the oxidative metabolism of lipids and detoxification of reactive oxygen species (ROS) …
the oxidative metabolism of lipids and detoxification of reactive oxygen species (ROS) …