Allelic imbalance of chromatin accessibility in cancer identifies candidate causal risk variants and their mechanisms
While many germline cancer risk variants have been identified through genome-wide
association studies (GWAS), the mechanisms by which these variants operate remain …
association studies (GWAS), the mechanisms by which these variants operate remain …
Post-GWAS in prostate cancer: from genetic association to biological contribution
Genome-wide association studies (GWAS) have been successful in deciphering the genetic
component of predisposition to many human complex diseases including prostate cancer …
component of predisposition to many human complex diseases including prostate cancer …
[PDF][PDF] A 17‐beta‐hydroxysteroid dehydrogenase 13 variant protects from hepatocellular carcinoma development in alcoholic liver disease
Recently, a loss of function variant (rs72613567) in 17‐beta‐hydroxysteroid dehydrogenase
13 (HSD17B13) has been identified as protective of nonalcoholic (NAFLD) and alcoholic …
13 (HSD17B13) has been identified as protective of nonalcoholic (NAFLD) and alcoholic …
NyuWa Genome resource: a deep whole-genome sequencing-based variation profile and reference panel for the Chinese population
The lack of haplotype reference panels and whole-genome sequencing resources specific
to the Chinese population has greatly hindered genetic studies in the world's largest …
to the Chinese population has greatly hindered genetic studies in the world's largest …
Analysis of 153 115 patients with hematological malignancies refines the spectrum of familial risk
Estimating familial cancer risks is clinically important in being able to discriminate between
individuals in the population at differing risk for malignancy. To gain insight into the familial …
individuals in the population at differing risk for malignancy. To gain insight into the familial …
Statistical methods for genome-wide association studies
Genome-wide association studies (GWAS) detect common genetic variants associated with
complex disorders. With their comprehensive coverage of common single nucleotide …
complex disorders. With their comprehensive coverage of common single nucleotide …
Causal link between gut microbiota and four types of pancreatitis: a genetic association and bidirectional Mendelian randomization study
K Wang, X Qin, T Ran, Y Pan, Y Hong, J Wang… - Frontiers in …, 2023 - frontiersin.org
Background A number of recent observational studies have indicated a correlation between
the constitution of gut microbiota and the incidence of pancreatitis. Notwithstanding …
the constitution of gut microbiota and the incidence of pancreatitis. Notwithstanding …
Machine learning and big data provide crucial insight for future biomaterials discovery and research
J Kerner, A Dogan, H von Recum - Acta Biomaterialia, 2021 - Elsevier
Abstract Machine learning have been widely adopted in a variety of fields including
engineering, science, and medicine revolutionizing how data is collected, used, and stored …
engineering, science, and medicine revolutionizing how data is collected, used, and stored …
Surface enhanced Raman spectroscopy for tumor nucleic acid: Towards cancer diagnosis and precision medicine
L Wu, A Dias, L Dieguez - Biosensors and Bioelectronics, 2022 - Elsevier
Cancer is the second leading cause of death worldwide. Early diagnosis and
personalization of treatment have become effective routes to control the increasing mortality …
personalization of treatment have become effective routes to control the increasing mortality …
Lifestyles, genetics, and future perspectives on gastric cancer in east Asian populations
H Katoh, S Ishikawa - Journal of human genetics, 2021 - nature.com
The prevalence of gastric cancer (GC) differs among regions worldwide, with the highest
occurrence in east Asia. Thus, its etiology, with respect to ethnic background, environmental …
occurrence in east Asia. Thus, its etiology, with respect to ethnic background, environmental …