Genome-wide association studies have provided evidence for inherited genetic
predisposition to chronic lymphocytic leukemia (CLL). To gain insight into the mechanisms …

Simple Summary The cancer genome has been exhaustively studied upon the advent of
Next-Generation Sequencing technologies. Coding and non-coding sequences have been …

Research in the human genome sciences generates a substantial amount of genetic data for
hundreds of thousands of individuals, which concomitantly increases the number of variants …

Genome-wide association studies have identified 270 loci conferring risk for prostate cancer
(PCa), yet the underlying biology and clinical impact remain to be investigated. Here we …

Cancer initiation is driven by the cooperation between genetic and epigenetic aberrations
that disrupt gene regulatory programs critical to maintaining specialized cellular functions …

Research into factors affecting treatment response or survival in patients with cancer
frequently involves cohorts that span the most common range of clinical outcomes, as such …

Recent genome-wide association studies of glioma have led to the discovery of single
nucleotide polymorphisms (SNPs) at 25 loci influencing risk. Gliomas are heterogeneous …

Uterine leiomyomas (ULs) are benign smooth muscle tumors that are common in
premenopausal women. Somatic alterations in MED12, HMGA2, FH, genes encoding …

Tamoxifen is part of the standard of care of endocrine therapy for adjuvant treatment of
breast cancer. However, survival outcomes with tamoxifen are highly variable. The …

Genome‐wide association studies (GWAS) have identified many genetic risk variants for
cancers. The utility of these variants in assessing risk of esophageal, gastric and …