Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

The class of serotonin and norepinephrine reuptake inhibitors (SNRIs) now comprises three
medications: venlafaxine, milnacipran, and duloxetine. These drugs block the reuptake of …

Patients with multiple somatic symptoms are common in primary care settings, in which more
than half of all visits are for somatic complaints. 1 For some of the most common symptoms …

Objective: To compare early sustained response rates between antidepressant-and placebo-
treated adults with major depressive disorder. Data Sources: Medline/Pubmed were …

BACKGROUND:: Duloxetine hydrochloride has recently been approved by the US Food and
Drug Administration for the treatment of major depressive disorder (MDD). Duloxetine is a …

Rationale Positron emission tomography (PET) has been utilized for determining the dosage
of antipsychotic drugs. To evaluate the dosage of antidepressants such as selective …

Background Multimodal analgesia is a fundamental part of modern surgery and enhanced
recovery pathways. Duloxetine, a serotonin and norepinephrine reuptake inhibitor, has been …

BACKGROUND: Anhedonia and lack of motivation are core symptoms of major depressive
disorder (MDD). Neuroimaging studies in MDD patients have shown reductions in reward …

Objective: Despite promising new therapies, bipolar depression remains difficult to treat. Up
to half of patients do not respond adequately to currently approved treatments. This study …

Painful physical symptoms are common elements within mood disorders and provide a
therapeutic challenge when such patients attribute their pain to causes other than the mood …