Gene-based therapy is the intentional modulation of gene expression in specific cells to treat
pathological conditions. This modulation is accomplished by introducing exogenous nucleic …

Efficient intracellular delivery of proteins is needed to fully realize the potential of protein
therapeutics. Current methods of protein delivery commonly suffer from low tolerance for …

Cardiovascular diseases are the leading cause of death globally and are associated with
increasing financial expenditure. With the availability of next-generation sequencing …

Intracellular delivery of messenger RNA (mRNA) has the potential to induce protein
production for many therapeutic applications. Although lipid nanoparticles have shown …

The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …

Messenger RNA as a therapeutic modality is becoming increasingly popular in the field of
gene therapy. The realization that nucleobase modifications can greatly enhance the …

Functional delivery of mRNA has high clinical potential. Previous studies established that
mRNAs can be delivered to cells in vitro and in vivo via RNA-loaded lipid nanoparticles …

mRNA vaccines are rapidly emerging as a powerful platform for infectious diseases because
they are well tolerated, immunogenic, and scalable and are built on precise but adaptable …

Background: The adult mammalian heart has limited regenerative capacity, mostly
attributable to postnatal cardiomyocyte cell cycle arrest. In the last 2 decades, numerous …

Being a transient carrier of genetic information, mRNA could be a versatile, flexible, and safe
means for protein therapies. While recent findings highlight the enormous therapeutic …