Safety evaluation of lipid nanoparticle–formulated modified mRNA in the Sprague-Dawley rat and cynomolgus monkey
M Sedic, JJ Senn, A Lynn, M Laska… - Veterinary …, 2018 - journals.sagepub.com
The pharmacology, pharmacokinetics, and safety of modified mRNA formulated in lipid
nanoparticles (LNPs) were evaluated after repeat intravenous infusion to rats and monkeys …
nanoparticles (LNPs) were evaluated after repeat intravenous infusion to rats and monkeys …
Modified polynucleotides for the production of biologics and proteins associated with human disease
S Bancel, T Chakraborty, A De Fougerolles… - US Patent …, 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49235350&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
49235350&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
mRNA transcript therapy
D Weissman - Expert review of vaccines, 2015 - Taylor & Francis
mRNA is the central molecule of all forms of life. It is generally accepted that current life on
Earth descended from an RNA world. mRNA, after its first therapeutic description in 1992 …
Earth descended from an RNA world. mRNA, after its first therapeutic description in 1992 …
[HTML][HTML] Drug and cell delivery for cardiac regeneration
CL Hastings, ET Roche, E Ruiz-Hernandez… - Advanced drug delivery …, 2015 - Elsevier
The spectrum of ischaemic cardiomyopathy, encompassing acute myocardial infarction to
congestive heart failure is a significant clinical issue in the modern era. This group of …
congestive heart failure is a significant clinical issue in the modern era. This group of …
[HTML][HTML] Biocompatible, purified VEGF-A mRNA improves cardiac function after intracardiac injection 1 week post-myocardial infarction in swine
L Carlsson, JC Clarke, C Yen, F Gregoire… - … Therapy-Methods & …, 2018 - cell.com
mRNA can direct dose-dependent protein expression in cardiac muscle without genome
integration, but to date has not been shown to improve cardiac function in a safe, clinically …
integration, but to date has not been shown to improve cardiac function in a safe, clinically …
Emergence of synthetic mRNA: In vitro synthesis of mRNA and its applications in regenerative medicine
The field of gene therapy has evolved over the past two decades after the first introduction of
nucleic acid drugs, such as plasmid DNA (pDNA). With the development of in vitro …
nucleic acid drugs, such as plasmid DNA (pDNA). With the development of in vitro …
Fast revascularization of the injured area is essential to support zebrafish heart regeneration
Zebrafish have a remarkable capacity to regenerate their heart. Efficient replenishment of
lost tissues requires the activation of different cell types including the epicardium and …
lost tissues requires the activation of different cell types including the epicardium and …
Modified polynucleotides for the production of secreted proteins
T Chakraborty, A De Fougerolles - US Patent 9,192,651, 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49235350&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
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Biomaterials for mRNA delivery
Messenger RNA (mRNA) has recently emerged with remarkable potential as an effective
alternative to DNA-based therapies because of several unique advantages. mRNA does not …
alternative to DNA-based therapies because of several unique advantages. mRNA does not …