Annexins constitute an evolutionary conserved multigene protein superfamily characterized
by their ability to interact with biological membranes in a calcium dependent manner. They …

Routine manipulation of the mouse genome has become a landmark in biomedical
research. Traits that are only associated with advanced developmental stages can now be …

Disruption of the plasma membrane often accompanies cellular injury, and in muscle,
plasma membrane resealing is essential for efficient recovery from injury. Muscle …

Cholesterol accumulation in late endosomes is a prevailing phenotype of Niemann-Pick
type C1 (NPC1) mutant cells. Likewise, annexin A6 (AnxA6) overexpression induces a …

Background The toxicity of amyloid-β (Aβ) peptide present in the brain of Alzheimer's
disease (AD) patients is thought to be mediated via the increased secretion of pro …

Abstract Annexin A6 (AnxA6) is a member of a conserved superfamily of Ca2+‑dependent
membrane‑binding annexin proteins. It participates in membrane and cytoskeleton …

Annexins are a highly conserved protein family that bind to phospholipids in a calcium (Ca
2+)–dependent manner. Studies with purified annexins, as well as overexpression and …

Phytosterols (PSs) are a group of plant derived steroid alcohols, with wide occurrence in
vegetables and fruits. They are integral components of plant cell membranes, having …

Major depressive disorder (MDD) involves changes in lipid metabolism, but previous
findings are contradictory. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is …

The spatiotemporal regulation of calcium (Ca2+) storage in late endosomes (LE) and
lysosomes (Lys) is increasingly recognized to influence a variety of membrane trafficking …