High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1
J McNeish, RJ Aiello, D Guyot, T Turi… - Proceedings of the …, 2000 - National Acad Sciences
Recently, the human ATP-binding cassette transporter-1 (ABC1) gene has been
demonstrated to be mutated in patients with Tangier disease. To investigate the role of the …
demonstrated to be mutated in patients with Tangier disease. To investigate the role of the …
ABCA1 and nascent HDL biogenesis
S Wang, JD Smith - Biofactors, 2014 - Wiley Online Library
ABCA1 mediates the secretion of cellular free cholesterol and phospholipids to an
extracellular acceptor, apolipoprotein AI, to form nascent high‐density lipoprotein (HDL) …
extracellular acceptor, apolipoprotein AI, to form nascent high‐density lipoprotein (HDL) …
Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma
We performed a genome-wide association study for primary open-angle glaucoma (POAG)
in 1,007 cases with high-pressure glaucoma (HPG) and 1,009 controls from southern China …
in 1,007 cases with high-pressure glaucoma (HPG) and 1,009 controls from southern China …
Regulation of cholesterol homeostasis
L Goedeke, C Fernández-Hernando - Cellular and Molecular Life Sciences, 2012 - Springer
Cholesterol homeostasis is among the most intensely regulated processes in biology. Since
its isolation from gallstones at the time of the French Revolution, cholesterol has been …
its isolation from gallstones at the time of the French Revolution, cholesterol has been …
Identification of macrophage liver X receptors as inhibitors of atherosclerosis
RK Tangirala, ED Bischoff, SB Joseph… - Proceedings of the …, 2002 - National Acad Sciences
Recent studies have identified the liver X receptors (LXRα and LXRβ) as important
regulators of cholesterol metabolism and transport. LXRs control transcription of genes …
regulators of cholesterol metabolism and transport. LXRs control transcription of genes …
Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice
R Koldamova, M Staufenbiel, I Lefterov - Journal of Biological Chemistry, 2005 - ASBMB
ABCA1 (ATP-binding cassette transporter A1) is a major regulator of cholesterol efflux and
high density lipoprotein (HDL) metabolism. Mutations in human ABCA1 cause severe HDL …
high density lipoprotein (HDL) metabolism. Mutations in human ABCA1 cause severe HDL …
[HTML][HTML] cDNA microarray analysis of gene expression profiles in human fibroblast cells irradiated with red light
S Song, Y Zhang, CC Fong, CH Tsang, Z Yang… - Journal of investigative …, 2003 - Elsevier
In this paper, the cDNA microarray technique was used to investigate the gene expression
profiles of human fibroblasts irradiated by low-intensity red light. Proliferation assays …
profiles of human fibroblasts irradiated by low-intensity red light. Proliferation assays …
Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune response
A key issue in the immune system is to generate specific cell types, often with opposing
activities. The mechanisms of differentiation and subtype specification of immune cells such …
activities. The mechanisms of differentiation and subtype specification of immune cells such …
Control of cholesterol metabolism and plasma high-density lipoprotein levels by microRNA-144
CM Ramírez, N Rotllan, AV Vlassov, A Dávalos… - Circulation …, 2013 - Am Heart Assoc
Rationale: Foam cell formation because of excessive accumulation of cholesterol by
macrophages is a pathological hallmark of atherosclerosis, the major cause of morbidity and …
macrophages is a pathological hallmark of atherosclerosis, the major cause of morbidity and …
Phosphatidylserine, a death knell
RA Schlegel, P Williamson - Cell Death & Differentiation, 2001 - nature.com
Virtually every cell in the body restricts phosphatidylserine (PS) to the inner leaflet of the
plasma membrane by energy-dependent transport from the outer to the inner leaflet of the …
plasma membrane by energy-dependent transport from the outer to the inner leaflet of the …