Molecular medicine has led to rapid advances in the characterization of hepatobiliary
transport systems that determine the uptake and excretion of bile salts and other biliary …

Here we demonstrate that the ABC transporter ABCG1 plays a critical role in lipid
homeostasis by controlling both tissue lipid levels and the efflux of cellular cholesterol to …

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that regulate lipid
and glucose metabolism and cellular differentiation. PPAR-α and PPAR-γ are both …

The liver X receptors (LXRs) are nuclear receptors that play central roles in the
transcriptional control of lipid metabolism. LXRs function as nuclear cholesterol sensors that …

LXRα is a nuclear receptor that has previously been shown to regulate the metabolic
conversion of cholesterol to bile acids. Here we define a role for this transcription factor in …

The mechanisms responsible for the inverse relationship between plasma high-density
lipoprotein (HDL) levels and atherosclerotic cardiovascular disease are poorly understood …

Several nuclear hormone receptors involved in lipid metabolism form obligate heterodimers
with retinoid X receptors (RXRs) and are activated by RXR agonists such as rexinoids …

Phosphatidylcholine (PC) is the major phospholipid component of all plasma lipoprotein
classes. PC is the only phospholipid which is currently known to be required for lipoprotein …

Plasma HDL levels have a protective role in atherosclerosis, yet clinical therapies to raise
HDL levels have remained elusive. Recent advances in the understanding of lipid …

There is considerable evidence that the antioxidant activity of high density lipoprotein (HDL)
is largely due to the paraoxonase-1 (PON1) located on it. Experiments with transgenic PON1 …