HDL metabolism represents a major target for the development of therapies intended to
reduce the risk of atherosclerotic cardiovascular disease. HDL metabolism is complex and …

Importantly, although liver and intestine ABCA1 may be the most critical for lipidating newly
synthesized lipid-free apoA-I, substantial additional cholesterol efflux to HDL occurs from …

Macrophage ATP-binding cassette transporter A1 (ABCA1), scavenger receptor class B type
I (SR-BI), and ABCG1 have been shown to promote cholesterol efflux to extracellular …

▪ Abstract The metabolic nuclear receptors act as metabolic and toxicological sensors,
enabling the organism to quickly adapt to environmental changes by inducing the …

Phosphatidylserine (PS) is a quantitatively minor membrane phospholipid that is
synthesized by prokaryotic and eukaryotic cells. In this review we focus on genes and …

Cholesterol is a multifacetted molecule. First, it serves as an essential membrane
component, as a cofactor for signaling molecules and as a precursor for steroid hormones; …

The liver X receptors α and β (LXRα and LXRβ) are members of the nuclear receptor family
of proteins that are critical for the control of lipid homeostasis in vertebrates. The …

Apolipoprotein E (apoE) secreted by macrophages in the artery wall exerts an important
protective effect against the development of atherosclerosis, presumably through its ability to …

Plasma HDL cholesterol levels are inversely related to risk for atherosclerosis. The ATP-
binding cassette, subfamily A, member 1 (ABCA1) mediates the rate-controlling step in HDL …

Although recent genome-wide association studies have called into question the causal
relationship between high-density lipoprotein (HDL) cholesterol levels and cardiovascular …