Cholesterol efflux pathways and other potential mechanisms involved in the athero‐protective effect of high density lipoproteins
AR Tall - Journal of internal medicine, 2008 - Wiley Online Library
Plasma high density lipoprotein (HDL) levels bear a strong independent inverse relationship
with atherosclerotic cardiovascular disease. Although HDL has anti‐oxidant, anti …
with atherosclerotic cardiovascular disease. Although HDL has anti‐oxidant, anti …
[HTML][HTML] Differential Phospholipid Substrates and Directional Transport by ATP-binding Cassette Proteins ABCA1, ABCA7, and ABCA4 and Disease-causing Mutants …
F Quazi, RS Molday - Journal of Biological Chemistry, 2013 - ASBMB
ABCA1, ABCA7, and ABCA4 are members of the ABCA subfamily of ATP-binding cassette
transporters that share extensive sequence and structural similarity. Mutations in ABCA1 …
transporters that share extensive sequence and structural similarity. Mutations in ABCA1 …
Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL
The concentration, composition, shape, and size of plasma high-density lipoprotein (HDL)
are determined by numerous proteins that influence its biogenesis, remodeling, and …
are determined by numerous proteins that influence its biogenesis, remodeling, and …
HDL as a target in the treatment of atherosclerotic cardiovascular disease
P Linsel-Nitschke, AR Tall - Nature reviews Drug discovery, 2005 - nature.com
Lipid abnormalities are among the key risk factors for cardiovascular disease. Indeed, lipid-
modifying drugs—in particular, the statins, which primarily lower plasma levels of low …
modifying drugs—in particular, the statins, which primarily lower plasma levels of low …
The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport
C Bergt, S Pennathur, X Fu, J Byun… - Proceedings of the …, 2004 - National Acad Sciences
Although oxidatively damaged lipoproteins are implicated in vascular injury, there is little
information regarding the role of high-density lipoprotein (HDL) oxidation in atherogenesis …
information regarding the role of high-density lipoprotein (HDL) oxidation in atherogenesis …
Overview: ABC transporters and human disease
MM Gottesman, SV Ambudkar - Journal of bioenergetics and …, 2001 - Springer
ABC transporters are found in all known organisms, and approximately 1,100 different
transporters belonging to this family have been described in the literature. The family is …
transporters belonging to this family have been described in the literature. The family is …
[HTML][HTML] ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein
ABCA1, an ATP-binding cassette transporter mutated in Tangier disease, promotes cellular
phospholipid and cholesterol efflux by loading free apoA-I with these lipids. This process …
phospholipid and cholesterol efflux by loading free apoA-I with these lipids. This process …
Reverse cholesterol transport and cholesterol efflux in atherosclerosis
R Ohashi, H Mu, X Wang, Q Yao, C Chen - Qjm, 2005 - academic.oup.com
Reverse cholesterol transport (RCT) is a pathway by which accumulated cholesterol is
transported from the vessel wall to the liver for excretion, thus preventing atherosclerosis …
transported from the vessel wall to the liver for excretion, thus preventing atherosclerosis …
[HTML][HTML] Mutations in lipid transporter ABCA12 in harlequin ichthyosis and functional recovery by corrective gene transfer
M Akiyama, Y Sugiyama-Nakagiri… - The Journal of …, 2005 - Am Soc Clin Investig
Harlequin ichthyosis (HI) is a devastating skin disorder with an unknown underlying cause.
Abnormal keratinocyte lamellar granules (LGs) are a hallmark of HI skin. ABCA12 is a …
Abnormal keratinocyte lamellar granules (LGs) are a hallmark of HI skin. ABCA12 is a …
[HTML][HTML] ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages
JF Oram, RM Lawn, MR Garvin, DP Wade - Journal of Biological Chemistry, 2000 - ASBMB
Lipid-poor high density lipoprotein apolipoproteins remove cholesterol and phospholipids
from cells by an active secretory pathway controlled by an ABC transporter called ABCA1 …
from cells by an active secretory pathway controlled by an ABC transporter called ABCA1 …